Biomolecular Condensates and Cancer.
| Autor: | Boija A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: annboija@wi.mit.edu., Klein IA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address: isaac_klein@dfci.harvard.edu., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer cell [Cancer Cell] 2021 Feb 08; Vol. 39 (2), pp. 174-192. Date of Electronic Publication: 2021 Jan 07. |
| DOI: | 10.1016/j.ccell.2020.12.003 |
| Abstrakt: | Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensates are membrane-less bodies, often formed by liquid-liquid phase separation, that compartmentalize protein and RNA molecules with related functions. New insights from condensate studies portend a profound transformation in our understanding of cellular dysregulation in cancer. Here we summarize key features of biomolecular condensates, note where they have been implicated-or will likely be implicated-in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensates, and discuss some of the questions that must be addressed to further advance our understanding and treatment of cancer. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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