Radiosynthesis of 18 F-fluoroethylated tracers via a simplified one-pot 18 F-fluoroethylation method using [ 18 F]fluoroethyl tosylate.

Autor: Kawamura K; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan. Electronic address: kawamura.kazunori@qst.go.jp., Kumata K; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan., Mori W; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan., Fujinaga M; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan., Kurihara Y; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan; SHI Accelerator Service Ltd., Tokyo, 141-0032, Japan., Ogawa M; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan; SHI Accelerator Service Ltd., Tokyo, 141-0032, Japan., Ohkubo T; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan; SHI Accelerator Service Ltd., Tokyo, 141-0032, Japan., Furutsuka K; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan; SHI Accelerator Service Ltd., Tokyo, 141-0032, Japan., Hashimoto H; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan., Nengaki N; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan; SHI Accelerator Service Ltd., Tokyo, 141-0032, Japan., Zhang MR; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-855, Japan.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2021 Mar; Vol. 169, pp. 109571. Date of Electronic Publication: 2020 Dec 26.
DOI: 10.1016/j.apradiso.2020.109571
Abstrakt: Recently, a straightforward one-pot method for 18 F-fluoroethylation without azeotropic drying of cyclotron-produced [ 18 F]F - was developed. In this study, we have attempted to simplify the automated radiosynthesis of two [ 18 F]fluoroethylated tracers, [ 18 F]FEDAC and [ 18 F]FET, using a desmethyl labeling precursor and [ 18 F]fluoroethyl tosylate, based on the above-mentioned method. The radiochemical yields of [ 18 F]FEDAC and [ 18 F]FET were 26 ± 3.7% (n = 5) and 14 ± 2.2% (n = 4), respectively, based on total [ 18 F]F - at the end of irradiation.
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Databáze: MEDLINE
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