What Animal Models Can Tell Us About Long-Term Psychiatric Symptoms in Sepsis Survivors: a Systematic Review.

Autor: Dal-Pizzol F; Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Brazil. fdpizzol@gmail.com., de Medeiros GF; Laboratoire de Neuropathologie Expérimentale, Institut Pasteur, 75015, Paris, France., Michels M; Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Brazil., Mazeraud A; Laboratory of Experimental Neuropathology, Institut Pasteur, 75015, Paris, France., Bozza FA; Laboratório de Medicina Intensiva, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), 21040-360, Rio de Janeiro, Brazil., Ritter C; Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Brazil., Sharshar T; Laboratoire de Neuropathologie Expérimentale, Institut Pasteur, 75015, Paris, France.; Laboratory of Experimental Neuropathology, Institut Pasteur, 75015, Paris, France.; Department of Neuro-Intensive Care Medicine, Sainte-Anne Hospital, Paris-Descartes University, 75015, Paris, France.
Jazyk: angličtina
Zdroj: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2021 Apr; Vol. 18 (2), pp. 1393-1413. Date of Electronic Publication: 2021 Jan 06.
DOI: 10.1007/s13311-020-00981-9
Abstrakt: Lower sepsis mortality rates imply that more patients are discharged from the hospital, but sepsis survivors often experience sequelae, such as functional disability, cognitive impairment, and psychiatric morbidity. Nevertheless, the mechanisms underlying these long-term disabilities are not fully understood. Considering the extensive use of animal models in the study of the pathogenesis of neuropsychiatric disorders, it seems adopting this approach to improve our knowledge of postseptic psychiatric symptoms is a logical approach. With the purpose of gathering and summarizing the main findings of studies using animal models of sepsis-induced psychiatric symptoms, we performed a systematic review of the literature on this topic. Thus, 140 references were reviewed, and most of the published studies suggested a time-dependent recovery from behavior alterations, despite the fact that some molecular alterations persist in the brain. This review reveals that animal models can be used to understand the mechanisms that underlie anxiety and depression in animals recovering from sepsis.
(© 2021. The American Society for Experimental NeuroTherapeutics, Inc.)
Databáze: MEDLINE
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