Functions of CD169 positive macrophages in human diseases (Review).

Autor: Liu Y; Department of Cell Biology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China., Xia Y; Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China., Qiu CH; Department of Cell Biology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
Jazyk: angličtina
Zdroj: Biomedical reports [Biomed Rep] 2021 Feb; Vol. 14 (2), pp. 26. Date of Electronic Publication: 2020 Dec 17.
DOI: 10.3892/br.2020.1402
Abstrakt: CD169 + macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169 + macrophages are present in multiple tissues and organs throughout the body and are primarily expressed in secondary lymphoid organs. These cells are primarily divided across three locations in secondary lymphoid organs: The metallophilic marginal zone of the spleen, the subcapsular sinus and the medulla of the lymph nodes. Due to their unique location distribution in vivo and the presence of the CD169 molecule on their surfaces, CD169 + macrophages are reported to serve important roles in several processes, such as phagocytosis, antigen presentation, immune tolerance, viral infection and inflammatory responses. At the same time, it has been reported that CD169 + macrophages may also serve an important role in anti-tumour immunity. The present review focuses on the research progress surrounding the function of CD169 + macrophages in a variety of diseases, such as viral infection, autoimmune diseases and tumours.
(Copyright: © Liu et al.)
Databáze: MEDLINE
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