Combining Gamma With Alpha and Beta Power Modulation for Enhanced Cortical Mapping in Patients With Focal Epilepsy.

Autor:	Archila-Meléndez ME; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Neuroscientific MR-Physics Research Group, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany.; Technical University of Munich Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany., Valente G; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, Netherlands., Gommer ED; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht University, Maastricht, Netherlands., Correia JM; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Basque Center on Cognition, Brain and Language (BCBL), Donostia-San Sebastian, Spain.; Centre for Biomedical Research (CBMR)/Department of Psychology, Universidade do Algarve, Faro, Portugal., Ten Oever S; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, Netherlands., Peters JC; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, Netherlands.; Department of Vision & Cognition, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands., Reithler J; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, Netherlands.; Department of Vision & Cognition, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands., Hendriks MPH; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, Netherlands.; Department of Neurosurgery, Maastricht University Medical Center Maastricht, Maastricht University, Maastricht, Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Cornejo Ochoa W; Grupo Pediaciencias, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia., Schijns OEMG; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, Netherlands.; Department of Neurosurgery, Maastricht University Medical Center Maastricht, Maastricht University, Maastricht, Netherlands.; School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, Netherlands., Dings JTA; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, Netherlands.; Department of Neurosurgery, Maastricht University Medical Center Maastricht, Maastricht University, Maastricht, Netherlands., Hilkman DMW; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht University, Maastricht, Netherlands.; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, Netherlands., Rouhl RPW; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, Netherlands.; School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, Netherlands.; Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands., Jansma BM; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, Netherlands., van Kranen-Mastenbroek VHJM; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht University, Maastricht, Netherlands.; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, Netherlands.; Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands., Roberts MJ; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.; Center for Integrative Neuroscience (CIN), Maastricht University, Maastricht, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2020 Dec 21; Vol. 14, pp. 555054. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
DOI:	10.3389/fnhum.2020.555054
Abstrakt:	About one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping (ESM) is the gold standard for the identification of "eloquent" areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity (55-200 Hz) recorded with extraoperative electrocorticography (ECoG) during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha (8-12 Hz) and beta (15-25 Hz) bands could further improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy (age: 35.9 ± 9.1 years, range: 22-48, 8 females, 9 right handed) participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model (GLM) approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic (ROC) curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient's degree of attention to the stimulus. We show that diagnostic ability can be increased by 3-5% by combining gamma and alpha and by 7.5-11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2020 Archila-Meléndez, Valente, Gommer, Correia, ten Oever, Peters, Reithler, Hendriks, Cornejo Ochoa, Schijns, Dings, Hilkman, Rouhl, Jansma, van Kranen-Mastenbroek and Roberts.)
Databáze:	MEDLINE
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