Distinct network topology in Alzheimer's disease and behavioral variant frontotemporal dementia.

Autor: Ng ASL; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore, Singapore.; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Wang J; Centre for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ng KK; Centre for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chong JSX; Centre for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Qian X; Centre for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lim JKW; Centre for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan YJ; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore, Singapore.; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Yong ACW; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore, Singapore., Chander RJ; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore, Singapore., Hameed S; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore., Ting SKS; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore., Kandiah N; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore, Singapore.; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Zhou JH; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore. helen.zhou@nus.edu.sg.; Centre for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. helen.zhou@nus.edu.sg.; Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. helen.zhou@nus.edu.sg.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Jan 06; Vol. 13 (1), pp. 13. Date of Electronic Publication: 2021 Jan 06.
DOI: 10.1186/s13195-020-00752-w
Abstrakt: Background: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) cause distinct atrophy and functional disruptions within two major intrinsic brain networks, namely the default network and the salience network, respectively. It remains unclear if inter-network relationships and whole-brain network topology are also altered and underpin cognitive and social-emotional functional deficits.
Methods: In total, 111 participants (50 AD, 14 bvFTD, and 47 age- and gender-matched healthy controls) underwent resting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessments. Functional connectivity was derived among 144 brain regions of interest. Graph theoretical analysis was applied to characterize network integration, segregation, and module distinctiveness (degree centrality, nodal efficiency, within-module degree, and participation coefficient) in AD, bvFTD, and healthy participants. Group differences in graph theoretical measures and empirically derived network community structures, as well as the associations between these indices and cognitive performance and neuropsychiatric symptoms, were subject to general linear models, with age, gender, education, motion, and scanner type controlled.
Results: Our results suggested that AD had lower integration in the default and control networks, while bvFTD exhibited disrupted integration in the salience network. Interestingly, AD and bvFTD had the highest and lowest degree of integration in the thalamus, respectively. Such divergence in topological aberration was recapitulated in network segregation and module distinctiveness loss, with AD showing poorer modular structure between the default and control networks, and bvFTD having more fragmented modules in the salience network and subcortical regions. Importantly, aberrations in network topology were related to worse attention deficits and greater severity in neuropsychiatric symptoms across syndromes.
Conclusions: Our findings underscore the reciprocal relationships between the default, control, and salience networks that may account for the cognitive decline and neuropsychiatric symptoms in dementia.
Databáze: MEDLINE
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