A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature.

Autor: Patel SH; Division of Medical Oncology, The Ohio State University Wexner Medical Center, 1310D Lincoln Tower, 1800 Cannon Dr., Columbus, OH, 43210, USA., Saito YD; The Queen's Medical Center - West Oahu Queen's Cancer Center - West Oahu, Sullivan Care Center, 91-2127 Fort Weaver Road, Ewa Beach, HI, 96706, USA., Li Z; Department of Pathology, The Ohio State University, 410 W 10th AveN337B Doan Hall, Columbus, OH, 43210-1267, USA., Ramaswamy B; Division of Medical Oncology, The Ohio State University Wexner Medical Center, 1310D Lincoln Tower, 1800 Cannon Dr., Columbus, OH, 43210, USA.; The Ohio State University Comprehensive Cancer Center, The Ohio State University, 410 W 12th Avenue, Columbus, OH, 43210, USA., Stiff A; The Ohio State University Comprehensive Cancer Center, The Ohio State University, 410 W 12th Avenue, Columbus, OH, 43210, USA., Kassem M; Division of Medical Oncology, The Ohio State University Wexner Medical Center, 1310D Lincoln Tower, 1800 Cannon Dr., Columbus, OH, 43210, USA., Wesolowski R; Division of Medical Oncology, The Ohio State University Wexner Medical Center, 1310D Lincoln Tower, 1800 Cannon Dr., Columbus, OH, 43210, USA. Robert.Wesolowski@osumc.edu.; The Ohio State University Comprehensive Cancer Center, The Ohio State University, 410 W 12th Avenue, Columbus, OH, 43210, USA. Robert.Wesolowski@osumc.edu.
Jazyk: angličtina
Zdroj: Journal of medical case reports [J Med Case Rep] 2021 Jan 07; Vol. 15 (1), pp. 4. Date of Electronic Publication: 2021 Jan 07.
DOI: 10.1186/s13256-020-02615-2
Abstrakt: Background: Breast cancer is one of the most common causes of brain metastases. However, the presence of isolated central nervous system (CNS) metastatic disease early in the course of disease relapse is a rare event in cases of hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer.
Case Presentation: We summarize the clinical course of a pre-menopausal, 39-year old Caucasian female with history of operable, hormone receptor positive, HER2 negative breast cancer who was initially treated with curative-intend therapy but who unfortunately developed solitary metastatic lesion in the left thalamus. A biopsy of the lesion confirmed the presence of hormone receptor positive, HER2 negative metastatic breast cancer. Patient's CNS metastases continued to progress without any evidence of metastatic disease outside of the central nervous system and she eventually passed away about 5 years after the date of her initial diagnosis and 18 months following the diagnosis with brain metastasis.
Conclusion: Based on our case, although rare, patients with treated, operable, hormone receptor positive, HER2 negative breast cancer can present with solitary brain metastasis as the only sign of disease recurrence.
Databáze: MEDLINE
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