M1 macrophages involved in the pathogenesis of placental chronic villitis of unknown etiology.

Autor:	Scarini JF; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.; Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil., Rodrigues NM; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Sabino WL; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Soares C; Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil., Morais TML; Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil., de Lima-Souza RA; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.; Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil., Crescencio LR; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.; Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil., Gondak RO; Department of Pathology, School of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Mariano FV; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Altemani A; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Egal ESA; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.; Department of Pathology, School of Medicine, University of Utah (UU), Salt Lake City, UT, USA.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 4847-4852. Date of Electronic Publication: 2021 Jan 06.
DOI:	10.1080/14767058.2020.1869930
Abstrakt:	Introduction: Placental villitis is characterized by the presence of inflammatory infiltrate in the placental villous. The objective of this study was to characterize in villitis of unknown etiology (VUE) of the human placentas the subpopulation of M1, important effector cells, and M2 macrophages, immunoregulatory cells. Methods: Sixteen cases of VUE and three control placentas were examined using immunohistochemistry with antibodies for CD3, CD68, CD11c, and CD163. Results: CD11c appeared predominantly in the inflamed villi when compared to the normal areas ( p <.001). These cells corresponded to 41.2% of the macrophage population in the inflamed area and were mainly present inside the villi (36%). With regards to CD163, these cells tended to be in higher amounts in the inflamed villi when compared to CD11c and normal areas. Discussion: We conclude that the almost exclusive presence of M1 macrophages in the inflamed areas suggests the influence of these cells in the pathogenesis VUE. The greater amount of M2 in villitis and normal areas suggests a possible immunoregulatory mechanism of the inflammatory process in VUE.
Databáze:	MEDLINE
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