Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients.

Autor:	Boey L; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Bosmans E; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Ferreira LB; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Heyvaert N; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Nelen M; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Smans L; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Tuerlinckx H; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Roelants M; Environment and Health, Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium., Claes K; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium., Derdelinckx I; Department of General Internal Medicine, University Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium., Janssens W; Department of Respiratory Diseases, University Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium., Mathieu C; Department of Endocrinology, University Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium., Van Cleemput J; Department of Cardiology, University Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium., Vos R; Department of Respiratory Diseases-Lung Transplantation Unit, University Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium., Desombere I; NRC Bordetella Pertussis and NRC Toxigenic Corynebacteria, Sciensano (Public Health Belgium), Engelandstraat 642, 1180 Ukkel, Belgium., Vandermeulen C; Department of Public Health and Primary Care, Leuven University Vaccinology Center, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium.; Environment and Health, Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 35, P.O. Box 7001, 3000 Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2021 Jan 04; Vol. 9 (1). Date of Electronic Publication: 2021 Jan 04.
DOI:	10.3390/vaccines9010018
Abstrakt:	Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) ( n = 172), DM2 ( n = 77), chronic kidney disease ( n = 130), chronic obstructive pulmonary disease (COPD) ( n = 170), heart failure ( n = 77), HIV ( n = 196) and solid organ transplant (SOT) recipients ( n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher ( p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age ( p < 0.001). Tetanus seroprotection was less reached in women ( p < 0.001) and older age groups ( p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis.
Databáze:	MEDLINE
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