From baker's yeast to genetically modified budding yeasts: the scientific evolution of bioethanol industry from sugarcane.

Autor:	Ceccato-Antonini SR; Laboratory of Agricultural and Molecular Microbiology, Dept Tecnologia Agroindustrial e Socioeconomia Rural, Centro de Ciências Agrárias, Universidade Federal de São Carlos, Via Anhanguera, km 174, 13600-970 Araras, São Paulo State, Brazil., Covre EA; Laboratory of Agricultural and Molecular Microbiology, Dept Tecnologia Agroindustrial e Socioeconomia Rural, Centro de Ciências Agrárias, Universidade Federal de São Carlos, Via Anhanguera, km 174, 13600-970 Araras, São Paulo State, Brazil.
Jazyk:	angličtina
Zdroj:	FEMS yeast research [FEMS Yeast Res] 2021 Jan 06; Vol. 20 (8).
DOI:	10.1093/femsyr/foaa065
Abstrakt:	The peculiarities of Brazilian fuel ethanol fermentation allow the entry of native yeasts that may dominate over the starter strains of Saccharomyces cerevisiae and persist throughout the sugarcane harvest. The switch from the use of baker's yeast as starter to selected budding yeasts obtained by a selective pressure strategy was followed by a wealth of genomic information that enabled the understanding of the superiority of selected yeast strains. This review describes how the process of yeast selection evolved in the sugarcane-based bioethanol industry, the selection criteria and recent advances in genomics that could advance the fermentation process. The prospective use of genetically modified yeast strains, specially designed for increased robustness and product yield, with special emphasis on those obtained by the CRISPR (clustered regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) genome-editing approach, is discussed as a possible solution to confer higher performance and stability to the fermentation process for fuel ethanol production. (© The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.)
Databáze:	MEDLINE
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