Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort.

Autor:	Magnago RPL; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil., Barauna VG; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil., Brun BF; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil., Lo Prete AC; Universidade Federal de São Paulo, Escola Paulista de Medicina - EPM/Unifesp, São Paulo, SP, Brazil.; Universidade São Judas - USJ, São Paulo, SP, Brazil., Alvarenga AM; Universidade Federal de São Paulo, Escola Paulista de Medicina - EPM/Unifesp, São Paulo, SP, Brazil., Gastalho Campos LC; Universidade Estadual de Santa Cruz - UESC, Ilhéus, BA, Brazil., Rochette NFG; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil., Rangel LBA; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil., Faria RA; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil., Santos PCJL; Universidade Federal de São Paulo, Escola Paulista de Medicina - EPM/Unifesp, São Paulo, SP, Brazil., Silva IV; Universidade Federal do Espirito Santo - UFES, Vitória, ES, Brazil.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2020 Dec 15; Vol. 11 (50), pp. 4655-4660. Date of Electronic Publication: 2020 Dec 15 (Print Publication: 2020).
DOI:	10.18632/oncotarget.27744
Abstrakt:	The growth of the elderly population is a worldwide phenomenon and it is associated with chronic diseases, including dementia. In this scenario, the present study aimed to evaluate a possible association of estrogen receptor α polymorphisms with dementia in a Brazilian cohort. The subject sample was divided into two groups, control ( n = 105) and case ( n = 73), according to analysis of two predictive dementia tests (MMSE and CDR). The genotyping for the ERα PvuII (c.454-397T>C, rs2234693) and XbaI (c.454-351A>G, rs9340799) polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism. The ERα PvuII pp genotype was associated with higher odds ratio for dementia (OR = 3.42, 95% CI = 1.33-8.77, p = 0.01, in a model including covariates. A linear regression model identified significant associations of the ERα PvuII genotypes (independent variable) with CDR scale (dependent variable), β = 0.26 and p = 0.001. In conclusion, estrogen receptor α PvuII polymorphism is associated with dementia in a Brazilian cohort. This finding may be useful for the identification of a possible set of significant genetic and clinical biomarkers for better understanding pathophysiology, early diagnosis and management of dementia. Competing Interests: CONFLICTS OF INTEREST Authors have no conflicts of interest to declare. (Copyright: © 2020 Magnago et al.)
Databáze:	MEDLINE
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