Different Routes of Administration Lead to Different Oxidative Damage and Tissue Disorganization Levels on the Subacute Cadmium Toxicity in the Liver.

Autor: Mouro VGS; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil. vivianemouro@yahoo.com.; Department of Pharmacy, Faculty Univertix, Matipó, MG, 35367-000, Brazil. vivianemouro@yahoo.com., Ladeira LCM; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., Lozi AA; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., de Medeiros TS; Department of Pharmacy, Faculty Univertix, Matipó, MG, 35367-000, Brazil., Silva MR; Department of Pharmacy, Faculty Univertix, Matipó, MG, 35367-000, Brazil., de Oliveira EL; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., de Melo FCSA; Department of Animal Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., da Matta SLP; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil.; Department of Animal Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2021 Dec; Vol. 199 (12), pp. 4624-4634. Date of Electronic Publication: 2021 Jan 05.
DOI: 10.1007/s12011-020-02570-5
Abstrakt: The toxic effects of cadmium (Cd) on hepatic parameters are widely described in the literature. Experimental models often make use of the intraperitoneal route (i.p.) because it is easier to apply, while in the oral route, Cd poisoning in humans is best represented by allowing the metal to pass through the digestive system and be absorbed into the bloodstream. Thus, this study investigated the Cd exposure impact on the liver, by comparing both i.p. and oral routes, both in single dose, in addition to the oral route in fractional doses. Swiss adult male mice received CdCl 2 1.5 mg/kg i.p., 30 mg/kg oral single dose, and 4.28 mg/kg oral route in fractional doses for 7 consecutive days. Cd bioaccumulation was observed in all animals exposed to Cd. Hepatic concentrations of Ca and Fe increased only in the fractionated oral route. Liver activities of SOD and CAT increased only by oral single dose. GST decreased in all forms of oral administration, while MDA decreased only in i.p. route. Liver weight and HSI increased in the i.p. route, while organ volume increased in all forms of oral administration, and liver density increased in all animals exposed to Cd. In hepatic histomorphometry, the changes were more evident in oral administration, mainly in exposure to metal in a single dose. Thus, the subacute administration of Cd in different routes of administration leads to different changes in liver poisoning.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.)
Databáze: MEDLINE
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