Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma: A Multicentric Study.

Autor:	Yilmaz S; Department of Chest Disease, Eskisehir Osmangazi University Medical Faculty (Dr Yilmaz); Department of Chest Diseases, Gazi University Medical Faculty (Dr Demirci); Lung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University (Dr Metintas, Dr Ak, Dr Metintas), Eskisehir; Department of Chest Diseases, Necmettin Erbakan University Meram Medical Faculty, Konya (Dr Zamani); Department of Chest Diseases, Uludag University Medical Faculty, Bursa (Dr Guçlu, Dr Karadag); Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Science University (Dr Kabalak, Dr Yilmaz, Dr Kizilgoz, Dr Cengiz, Dr Ozdemirel, Dr Ozyurek, Dr Kavurgaci, Dr Erdogan); Sureyyapasa Chest Disease and Thoracic Surgery Training and Research Hospital (Dr Ozturk, Dr Kavas); Izmir Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Science University, Izmir (Dr Yilmaz, Dr Batum, Dr Komurcuoglu, Dr Alizoroglu); Department of Chest Diseases, Baskent University Medical Faculty (Dr Serifoglu, Dr Ulubay), Ankara; Department of Chest Diseases, Ondokuz Mayis University Medical Faculty, Samsun (Dr Unsal); Department of Chest Diseases, Celal Bayar University Medical Faculty, Manisa (Dr Celik); Department of Chest Diseases (Dr In); Department of Medical Oncology (Dr Aksoy), Firat University Medical Faculty, Elaziğ; Yedikule Chest Diseases and Chest Surgery Hospital (Dr Altin, Dr Gunluoglu), Health Science University, Istanbul, Turkey., Demirci NY, Metintas S, Zamani A, Karadag M, Guçlu OA, Kabalak PA, Yilmaz U, Ak G, Kizilgoz D, Ozturk A, Yilmaz U, Batum O, Kavas M, Serifoglu I, Unsal M, Komurcuoglu BE, Cengiz TI, Ulubay G, Ozdemirel TS, Ozyurek BA, Kavurgaci S, Alizoroglu D, Celik P, Erdogan Y, In E, Aksoy A, Altin S, Gunluoglu G, Metintas M
Jazyk:	angličtina
Zdroj:	Journal of occupational and environmental medicine [J Occup Environ Med] 2021 Mar 01; Vol. 63 (3), pp. 238-243.
DOI:	10.1097/JOM.0000000000002115
Abstrakt:	Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis. Competing Interests: Conflict of interest: There are no conflicts of interest of the authors regarding this manuscript. (Copyright © 2020 American College of Occupational and Environmental Medicine.)
Databáze:	MEDLINE
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