| Autor: |
de Figueiredo Sanches G; Laboratório de Biologia Molecular e Fisiologia de Estreptococos, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro State University, Rua São Francisco Xavier, 524 - PHLC 5º andar sala 501B-Maracanã, Rio de Janeiro, RJ, CEP 20550-013, Brazil.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA., Lannes-Costa PS; Laboratório de Biologia Molecular e Fisiologia de Estreptococos, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro State University, Rua São Francisco Xavier, 524 - PHLC 5º andar sala 501B-Maracanã, Rio de Janeiro, RJ, CEP 20550-013, Brazil., Cristoforêto MC; Laboratório de Biologia Molecular e Fisiologia de Estreptococos, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro State University, Rua São Francisco Xavier, 524 - PHLC 5º andar sala 501B-Maracanã, Rio de Janeiro, RJ, CEP 20550-013, Brazil., Doran KS; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA., Mattos-Guaraldi AL; Faculdade de Ciências Médicas, Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil., Nagao PE; Laboratório de Biologia Molecular e Fisiologia de Estreptococos, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro State University, Rua São Francisco Xavier, 524 - PHLC 5º andar sala 501B-Maracanã, Rio de Janeiro, RJ, CEP 20550-013, Brazil. pnagao@uol.com.br. |
| Abstrakt: |
Streptococcus agalactiae is a recognized pathogen associated with infections in neonates, elderly, and immunocompromised adults, particularly those with cancer. In the present investigation, clinical-epidemiological features, multidrug resistance profiles, and virulence genes of S. agalactiae strains isolated from cancer patients were investigated. S. agalactiae capsular distribution assays demonstrated that Ia (43.6%) and V (23.6%) types were predominantly detected among 55 clinical isolates tested; only one strain (GBS1428) was capsular type III/ST-17. The fbsB and hylB genes were detected in all isolates, while the iag, lmb, and fbsA genes were detected in 94.5%, 91%, and 91% of oncological isolates, respectively. The combination of PI-1 and PI-2a was the most common (60%) among S. agalactiae strains isolated from oncologic patients. S. agalactiae strains were resistant to tetracycline (85.5%), erythromycin (9%), and clindamycin (5.5%). Norfloxacin non-susceptible was detected in 7.3% of S. agalactiae strains. Our findings reinforce the need for S. agalactiae control measures in Brazil, including cancer patients. |
Full text from SpringerLink