| Autor: |
MacDonald T; Departments of Physiology, The University of Alberta, Edmonton, AB, Canada.; The Women's and Children's Health Research Institute, Edmonton, AB, Canada., Saurette M; Departments of Physiology, The University of Alberta, Edmonton, AB, Canada., Beggs MR; Departments of Physiology, The University of Alberta, Edmonton, AB, Canada.; The Women's and Children's Health Research Institute, Edmonton, AB, Canada., Todd Alexander R; Departments of Physiology, The University of Alberta, Edmonton, AB, Canada. todd2@ualberta.ca.; The Women's and Children's Health Research Institute, Edmonton, AB, Canada. todd2@ualberta.ca.; Departments of Pediatrics, The University of Alberta, Edmonton, AB, Canada. todd2@ualberta.ca. |
| Abstrakt: |
Phosphate is a multivalent ion critical for a variety of physiological functions including bone formation, which occurs rapidly in the developing infant. In order to ensure maximal bone mineralization, young animals must maintain a positive phosphate balance. To accomplish this, intestinal absorption and renal phosphate reabsorption are greater in suckling and young animals relative to adults. This review discusses the known intestinal and renal adaptations that occur in young animals in order to achieve a positive phosphate balance. Additionally, we discuss the ontogenic changes in phosphotropic endocrine signalling as it pertains to intestinal and renal phosphate handling, including several endocrine factors not always considered in the traditional dogma of phosphotropic endocrine signalling, such as growth hormone, triiodothyronine, and glucocorticoids. Finally, a proposed model of how these factors may contribute to achieving a positive phosphate balance during development is proposed. |
