Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Autor: Conti DV; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Darst BF; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Moss LC; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Saunders EJ; The Institute of Cancer Research, London, UK., Sheng X; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Chou A; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Schumacher FR; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Seidman Cancer Center, University Hospitals, Cleveland, OH, USA., Olama AAA; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Benlloch S; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Dadaev T; The Institute of Cancer Research, London, UK., Brook MN; The Institute of Cancer Research, London, UK., Sahimi A; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Hoffmann TJ; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genomic Medicine, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Biobank, Tokyo, Japan., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan., Fujita M; Laboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan., Muir K; Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Lophatananon A; Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Wan P; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Stevens VL; Behavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, GA, USA., Gapstur SM; Behavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, GA, USA., Carter BD; Behavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, GA, USA., Schleutker J; Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, Turku, Finland., Tammela TLJ; Department of Urology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sipeky C; Institute of Biomedicine, University of Turku, Turku, Finland., Auvinen A; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Southey MC; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Cybulski C; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Wokołorczyk D; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lubiński J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Neal DE; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.; University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK., Donovan JL; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hamdy FC; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK., Martin RM; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Bristol, Bristol, UK.; Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Nordestgaard BG; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen SF; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Weischer M; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Bojesen SE; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Røder MA; Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Iversen P; Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Batra J; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.; Translational Research Institute, Brisbane, Queensland, Australia., Chambers S; University of Technology, Sydney, New South Wales, Australia., Moya L; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.; Translational Research Institute, Brisbane, Queensland, Australia., Horvath L; Chris O'Brien Lifehouse (COBLH), Camperdown, Sydney, New South Wales, Australia.; Garvan Institute of Medical Research, Sydney, New South Wales, Australia., Clements JA; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.; Translational Research Institute, Brisbane, Queensland, Australia., Tilley W; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia., Risbridger GP; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Prostate Cancer Translational Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Gronberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Aly M; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, and Department of Urology, Karolinska University Hospital, Solna, Stockholm, Sweden.; Department of Urology, Karolinska University Hospital, Stockholm, Sweden., Szulkin R; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; SDS Life Science, Danderyd, Sweden., Eklund M; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Nordström T; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden., Pashayan N; Department of Applied Health Research, University College London, London, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Cambridge, UK.; Department of Applied Health Research, University College London, London, UK., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Cambridge, UK., Ghoussaini M; Open Targets, Wellcome Sanger Institute, Hinxton, UK., Travis RC; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Key TJ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Riboli E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Sellers TA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Lin HY; School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Weinstein SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Mucci LA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Giovannucci E; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Lindstrom S; Department of Epidemiology, University of Washington, Seattle, WA, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Hunter DJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Penney KL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Tangen CM; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Goodman PJ; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Thompson IM Jr; CHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, TX, USA., Hamilton RJ; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.; Department of Surgery (Urology), University of Toronto, Toronto, Ontario, Canada., Fleshner NE; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Finelli A; Division of Urology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Parent MÉ; Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Quebec, Canada.; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Ostrander EA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Geybels MS; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Koutros S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Freeman LEB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Stampfer M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA., Wolk A; Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Håkansson N; Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Andriole GL; Washington University School of Medicine, St Louis, MI, USA., Hoover RN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Sørensen KD; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Borre M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., Blot WJ; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; International Epidemiology Institute, Rockville, MD, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Yeboah ED; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Mensah JE; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Lu YJ; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK., Zhang HW; Second Military Medical University, Shanghai, China., Feng N; Wuxi Second Hospital, Nanjing Medical University, Wuxi, China., Mao X; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK., Wu Y; Department of Urology, First Affiliated Hospital, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China., Zhao SC; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Sun Z; The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, China., Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., McDonnell SK; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Schaid DJ; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., West CML; Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK., Burnet N; Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre, and The Christie NHS Foundation Trust, Manchester, UK., Barnett G; University of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Maier C; Humangenetik Tuebingen, Tuebingen, Germany., Schnoeller T; Department of Urology, University Hospital, Ulm, Germany., Luedeke M; genetikum, Neu-Ulm, Germany., Kibel AS; Division of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA., Drake BF; Washington University School of Medicine, St Louis, MI, USA., Cussenot O; Sorbonne Universite, Tenon Hospital, Paris, France., Cancel-Tassin G; Sorbonne Universite, Tenon Hospital, Paris, France.; CeRePP, Tenon Hospital, Paris, France., Menegaux F; Exposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France., Truong T; Exposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France., Koudou YA; CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Villejuif, France., John EM; Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Grindedal EM; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Maehle L; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Khaw KT; Clinical Gerontology Unit, University of Cambridge, Cambridge, UK., Ingles SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Stern MC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Vega A; Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Gómez-Caamaño A; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Fachal L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Rosenstein BS; Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kerns SL; Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA., Ostrer H; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA., Teixeira MR; Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Paulo P; Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.; Cancer Genetics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal., Brandão A; Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.; Cancer Genetics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal., Watya S; Uro Care, Kampala, Uganda., Lubwama A; Uro Care, Kampala, Uganda., Bensen JT; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fontham ETH; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Mohler J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA., Taylor JA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Kogevinas M; ISGlobal, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Llorca J; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; University of Cantabria-IDIVAL, Santander, Spain., Castaño-Vinyals G; ISGlobal, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Cannon-Albright L; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Teerlink CC; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Huff CD; Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Strom SS; Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Multigner L; University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Rennes, France., Blanchet P; CHU de Pointe-à-Pitre, University of the French Antilles, University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, France., Brureau L; CHU de Pointe-à-Pitre, University of the French Antilles, University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, France., Kaneva R; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria., Slavov C; Department of Urology and Alexandrovska University Hospital, Medical University of Sofia, Sofia, Bulgaria., Mitev V; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria., Leach RJ; Department of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Weaver B; Department of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Cuk K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Holleczek B; Saarland Cancer Registry, Saarbrücken, Germany., Saum KU; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Klein EA; Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.; Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH, USA., Hsing AW; Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Kittles RA; Division of Health Equities, Department of Population Sciences, City of Hope, Duarte, CA, USA., Murphy AB; Department of Urology, Northwestern University, Chicago, IL, USA., Logothetis CJ; Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Kim J; Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Steele L; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Ding YC; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Isaacs WB; James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Hennis AJM; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.; Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados., Carpten J; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Pandha H; Faculty of Health and Medical Sciences, The University of Surrey, Guildford, UK., Michael A; Faculty of Health and Medical Sciences, The University of Surrey, Guildford, UK., De Ruyck K; Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium., De Meerleer G; Department of Radiotherapy, Ghent University Hospital, Gent, Belgium., Ost P; Department of Radiotherapy, Ghent University Hospital, Gent, Belgium., Xu J; Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA., Razack A; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lim J; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Teo SH; Cancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Malaysia., Newcomb LF; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.; Department of Urology, University of Washington, Seattle, WA, USA., Lin DW; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.; Department of Urology, University of Washington, Seattle, WA, USA., Fowke JH; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA., Neslund-Dudas C; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Rybicki BA; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Gamulin M; Department of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Lessel D; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kulis T; Department of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Usmani N; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada., Singhal S; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada., Parliament M; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada., Claessens F; Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium., Joniau S; Department of Urology, University Hospitals Leuven, Leuven, Belgium., Van den Broeck T; Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium.; Department of Urology, University Hospitals Leuven, Leuven, Belgium., Gago-Dominguez M; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.; University of California San Diego, Moores Cancer Center, La Jolla, CA, USA., Castelao JE; Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo, Spain., Martinez ME; Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA., Larkin S; The University of Southampton, Southampton General Hospital, Southampton, UK., Townsend PA; Faculty of Health and Medical Sciences, The University of Surrey, Guildford, UK.; Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK., Aukim-Hastie C; Faculty of Health and Medical Sciences, The University of Surrey, Guildford, UK., Bush WS; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Aldrich MC; Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Crawford DC; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Srivastava S; Center for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA., Cullen JC; Center for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA., Petrovics G; Center for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA., Casey G; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Roobol MJ; Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands., Jenster G; Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands., van Schaik RHN; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands., Hu JJ; The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA., McKean-Cowdin R; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Torres M; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA., Mancuso N; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Van Den Eeden SK; Division of Research, Kaiser Permanente, Northern California, Oakland, CA, USA.; Department of Urology, University of California San Francisco, San Francisco, CA, USA., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Cook MB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Nakagawa H; Laboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan., Witte JS; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA.; Department of Urology, University of California San Francisco, San Francisco, CA, USA., Eeles RA; The Institute of Cancer Research, London, UK.; Royal Marsden NHS Foundation Trust, London, UK., Kote-Jarai Z; The Institute of Cancer Research, London, UK., Haiman CA; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA. haiman@usc.edu.
Jazyk: angličtina
Zdroj: Nature genetics [Nat Genet] 2021 Jan; Vol. 53 (1), pp. 65-75. Date of Electronic Publication: 2021 Jan 04.
DOI: 10.1038/s41588-020-00748-0
Abstrakt: Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
Databáze: MEDLINE