| Autor: |
Sarria-Santamera A; Department of Medicine, Nazarbayev University School of Medicine, Zhanibek-Kerey Khans Street, 5/1, Nur-Sultan 010000, Kazakhstan.; Spanish Network of Health Services Research and Chronic Diseases, REDISSEC, 28029 Madrid, Spain.; Instituto Mixto de Investigación Escuela Nacional de Sanidad-Universidad Nacional de Educación a Distancia, IMIENS-UNED, 28029 Madrid, Spain., Orazumbekova B; Department of Medicine, Nazarbayev University School of Medicine, Zhanibek-Kerey Khans Street, 5/1, Nur-Sultan 010000, Kazakhstan., Terzic M; Department of Medicine, Nazarbayev University School of Medicine, Zhanibek-Kerey Khans Street, 5/1, Nur-Sultan 010000, Kazakhstan.; Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, Turan Ave. 32, Nur-Sultan 010000, Kazakhstan.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Issanov A; Department of Medicine, Nazarbayev University School of Medicine, Zhanibek-Kerey Khans Street, 5/1, Nur-Sultan 010000, Kazakhstan., Chaowen C; Department of Surgery, Medical and Social Sciences, Faculty of Medicine, University of Alcalá, Alcalá de 288871 Henares, Spain., Asúnsolo-Del-Barco A; Department of Surgery, Medical and Social Sciences, Faculty of Medicine, University of Alcalá, Alcalá de 288871 Henares, Spain.; Department of Epidemiology and Biostatistics, City University of New York (CUNY) Graduate School of Public Health and Health Policy, New York, NY 10028, USA.; Ramón y Cajal Institute of Healthcare Research (IRYCIS), 28034 Madrid, Spain. |
| Abstrakt: |
There is still much controversy regarding the epidemiology of endometriosis. The objective of this work is to conduct a systematic review, and if possible, proceed with a meta-analysis of studies that have analyzed the incidence and prevalence of this condition among women in the general population. The inclusion criteria were papers published after 1997 that had reported data of the incidence or prevalence of endometriosis. The PubMed search engine was used to identify papers meeting the inclusion criteria from 1997 to 2019, with an additional manual search for the identification of potentially eligible studies. The search was limited to papers published in English. The risk of bias was assessed according to the Joanna Briggs Institute Critical Appraisal Checklist. As a result, 27 papers, which included a total of 28,660,652 women, were classified according to the type of design and sources of information in five subgroups. Pooled estimates of prevalence for studies with self-reported data were 0.05 (95% CI: 0.03; 0.06), 0.01 for population-based integrated information systems (95% CI: 0.01; 0.02), and 0.04 (95% CI 0.04; 0.05) in studies using other designs. The pooled incidence rate of endometriosis was: 1.36 per 1000 person-years (PY) (95% CI: 1.09; 1.63) for studies based on hospital discharges, 3.53 per 1000 PY (95% CI: 2.06; 4.99) for cohort studies, and 1.89 per 1000 PY (95% CI: 1.42; 2.37) for population-based integrated information systems. Meta-analysis indicated high heterogeneity based on I-squared statistics. This significant variability may not only be due to methodological issues and the specific limitations of the different designs and data analyzed, including case definitions and subject selection strategies, but also to the inherent heterogeneity of endometriosis. Epidemiological studies with appropriate study designs remain necessary to provide a valid estimation of the population burden of endometriosis. |
