Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases.

Autor: Aheget H; GENYO Centre for Genomics and Oncological Research, Genomic Medicine Department, Pfizer/University of Granada/Andalusian Regional Government, Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, Spain.; Department of Biology, Faculty of Sciences, University Abdelmalek Essaâdi, Tétouan 93000, Morocco., Mazini L; Center of Biological and Medical Sciences (CIAM), Mohammed VI Polytechnic University, Ben-Guerir 43152, Morocco., Martin F; GENYO Centre for Genomics and Oncological Research, Genomic Medicine Department, Pfizer/University of Granada/Andalusian Regional Government, Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, Spain., Belqat B; Department of Biology, Faculty of Sciences, University Abdelmalek Essaâdi, Tétouan 93000, Morocco., Marchal JA; Biomedical Research Institute (ibs. GRANADA), 18012 Granada, Spain.; Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain.; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain.; Excellence Research Unit Modeling Nature (MNat), University of Granada, 18016 Granada, Spain., Benabdellah K; GENYO Centre for Genomics and Oncological Research, Genomic Medicine Department, Pfizer/University of Granada/Andalusian Regional Government, Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2020 Dec 30; Vol. 13 (1). Date of Electronic Publication: 2020 Dec 30.
DOI: 10.3390/cancers13010084
Abstrakt: Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.
Databáze: MEDLINE
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