Paternal Biomass Smoke Exposure in Rats Produces Behavioral and Cognitive Alterations in the Offspring.

Autor: Sosedova LM; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia., Vokina VA; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia., Novikov MA; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia., Rukavishnikov VS; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia., Andreeva ES; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia., Zhurba OM; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia., Alekseenko AN; FSBSI East-Siberian Institute of Medical and Ecological Research, 664033 Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Toxics [Toxics] 2020 Dec 31; Vol. 9 (1). Date of Electronic Publication: 2020 Dec 31.
DOI: 10.3390/toxics9010003
Abstrakt: Particular concern at the present stage is the health effects of wildfires' smoke. The aim of the study was to determine the impact of paternal biomass-smoke exposure on offspring's behavior and cognitive abilities. Male rats were exposed to biomass smoke for four hours/day, five days/week, for four weeks. Average concentration of carbon monoxide and particulate matter of 2.5 μm PM 2.5 in the chamber during exposure were 28.7 ± 5.3 mg/m 3 and 1.9 ± 0.5 mg/m 3 , respectively. At the same time, high concentrations of furfural and acetaldehyde were detected in the air environment of the exposure chambers. Offspring was obtained by mating of experimental males with untreated females, immediately after the end of the exposure and after 60 days (long-term period). Offspring were tested by using the Morris water maze and open field at three months of age. Male and female offspring born by mating immediately after exposure demonstrated decreased exploratory behavior, locomotor activity, and spatial navigation, as well as increased anxiety levels. Locomotor and exploratory activity in rats of both sexes from progeny obtained after long-term exposure to smoke had no statistically significant differences when compared to the control; however, the females showed a high level of anxiety and impaired cognitive functions. The recovery period after biomass-smoke intoxication, comparable in duration of spermatogenesis in rats, was an important factor in reducing the risk of developing central nervous system (CNS) disorders in offspring.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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