Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood.

Autor: Azar N; Department of Psychology, Concordia University, Montréal, Québec, Canada; Sainte-Justine University Hospital Research Center, Québec, Canada., Booij L; Department of Psychology, Concordia University, Montréal, Québec, Canada; Sainte-Justine University Hospital Research Center, Québec, Canada; Department of Psychiatry and Addictology, Université de Montréal, Montréal, Québec, Canada., Muckle G; School of Psychology, Université Laval, Ville de Québec, Québec, Canada., Arbuckle TE; Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada., Séguin JR; Sainte-Justine University Hospital Research Center, Québec, Canada; Department of Psychiatry and Addictology, Université de Montréal, Montréal, Québec, Canada., Asztalos E; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada., Fraser WD; Sainte-Justine University Hospital Research Center, Québec, Canada; Centre de recherche du CHUS (CHU de Sherbrooke), Université de Sherbrooke, Sherbrooke, Québec, Canada., Lanphear BP; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Bouchard MF; Sainte-Justine University Hospital Research Center, Québec, Canada; Department of Environmental and Occupational Health, School of Public Health of the University of Montreal, Montréal, Québec, Canada. Electronic address: maryse.bouchard@umontreal.ca.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2021 Jan; Vol. 146, pp. 106296. Date of Electronic Publication: 2020 Dec 13.
DOI: 10.1016/j.envint.2020.106296
Abstrakt: Background: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with adverse neurodevelopmental outcomes in children, but evidence remains mixed regarding sex differences in this association.
Objective: To examine the prospective association between prenatal PBDE exposure and cognitive ability in young children, as well as potential sex differences.
Methods: The study was conducted in a multi-site Canadian pregnancy cohort recruited in 2008-11. PBDEs were measured in maternal plasma samples collected early in pregnancy. Cognitive ability was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) in children at age 3 years (mean = 3.4). Multiple linear regression was used to analyze the association between maternal PBDE plasma concentrations (lipid-standardized and log10-transformed) and Verbal, Performance, and Full Scale IQ scores on the whole sample and stratified by sex, adjusting for confounders.
Results: The sample was composed of 592 children (291 boys and 301 girls). A tenfold increase in maternal blood PBDE concentration (sum of BDE-47, -99, -100, and -153) was associated with lower Full Scale scores in boys (-3.4 points; 95% CI: -7.0, 0.1), after adjusting for confounders. BDE-47 was the congener with the highest concentrations in maternal blood and a tenfold increase in exposure was associated with significantly lower Full Scale IQ scores in boys (-4.4 points; 95% CI: -7.9, -0.9), after adjusting for confounders. Verbal and Performance IQ scores were similarly associated with PBDE exposure. Maternal blood PBDE concentrations were not associated with IQ scores in girls.
Conclusions: Prenatal exposure to background levels of PBDEs, especially BDE-47, was associated with lower IQ scores in boys, but not in girls. Our results support that exposure to PBDEs during early development may be sex-dependent and detrimental to a child's neurodevelopmental trajectory.
(Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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