| Autor: |
Medehouenou TCM; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada., Roy C; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada.; Centre de Toxicologie du Québec, INSPQ , Québec, Quebec, Canada., Tremblay PY; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada.; Centre de Toxicologie du Québec, INSPQ , Québec, Quebec, Canada., St-Jean A; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada., Meziou S; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada., Muckle G; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada.; School of Psychology, Université Laval , Québec, Quebec, Canada., Ayotte P; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada.; Centre de Toxicologie du Québec, INSPQ , Québec, Quebec, Canada.; Department of Social and Preventive Medicine, Université Laval , Québec, Quebec, Canada., Lucas M; Population Health and Optimal Health Practices Research Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval , Québec, Quebec, Canada.; Department of Social and Preventive Medicine, Université Laval , Québec, Quebec, Canada. |
| Abstrakt: |
In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers of T2D in school-aged Inuit children of Nunavik (Canada). Concentrations of metabolite were measured in plasma samples from a cross-sectional analysis of 248 children (mean age = 10.8 years). We assessed associations of plasma metabolites with adiposity measures (BMI, skinfold thicknesses) and T2D markers (insulin, glucose, adiponectin). Plasma concentrations of valine and tyrosine were higher in obese and overweight children compared to those of normal weight children (P < 0.05). An increment of 1-SD in BMI (SD = 3.3 kg/m 2 ) was statistically associated with an increment of 0.21 (95% CI: 0.08, 0.33) for valine, 0.15 (95% CI: 0.02, 0.27) for isoleucine and 0.17 (95% CI: 0.04, 0.29) for tyrosine. Insulin concentration increased with concentrations of all amino acids (P < 0.05) except methionine. None of the acylcarnitines measured were statistically significantly associated with adiposity or T2D biomarkers A signature of metabolites, particularly higher levels of branched-chain amino acids, might allow for early detection of T2D among school-aged Inuit children. |
