Primary gastric melanoma in a young woman: A case report.

Autor:	Long GJ; Department of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, Guangdong Province, China., Ou WT; Department of Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, Guangdong Province, China., Lin L; Department of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, , Zhanjiang 524002, Guangdong Province, China., Zhou CJ; Department of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, , Zhanjiang 524002, Guangdong Province, China. zhoucaipingren@163.com.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2020 Dec 26; Vol. 8 (24), pp. 6425-6431.
DOI:	10.12998/wjcc.v8.i24.6425
Abstrakt:	Background: Most melanomas identified in the stomach are metastatic. The primary gastric melanoma (PGM) is extremely rare. As such, clinical reports of PGM are scarce in the literature, lending to the challenge of diagnosis and treatment. Case Summary: A 31-year-old woman presented with a 1-mo history of dysphagia but no symptoms of abdominal pain, abdominal distension, nausea, vomiting, hematemesis, or melena. The patient reported an unintentional weight loss of 6 kg within that time. History-taking revealed no previous medical conditions or surgical events. Abdominal computed tomography at a local hospital had suggested gastric tumor. Endoscopic examination in our hospital found a large, irregular, black mass. Subsequent laparoscopic exploration found the tumor on the side of the stomach fundus penetrating through the serosa, and enlarged lymph nodes (groups 1, 3, 7, and 9) fused into a mass, surrounding the peripheral artery and inseparable. Postoperative immunohistochemistry suggested gastric malignant melanoma. Positron emission tomography-computed tomography confirmed PGM. Treatment with programmed cell death protein 1 antagonist (toripalimab) plus chemotherapy (paclitaxel) was initiated but discontinued upon tumor bleeding. At the last telephone follow-up, the patient reported poor general condition but was alive. Conclusion: Although unresolved and ongoing, this rare case of PGM expands the overall knowledge about this rare tumor's diagnosis and management. Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflicts of interest. (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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