Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.

Autor:	Lou YT; Department of Pediatrics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Li XL; Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, China., Wang Y; Department of Pediatrics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Ji GJ; Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China.; Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Anhui Province, Hefei, China., Zang YF; Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, China., Wang J; Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China., Feng JH; Department of Pediatrics, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2020 Dec 17; Vol. 11, pp. 543049. Date of Electronic Publication: 2020 Dec 17 (Print Publication: 2020).
DOI:	10.3389/fpsyt.2020.543049
Abstrakt:	Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventional frequency band (0.01-0.08 Hz) in TS. No published studies have reported abnormalities of local synchronization across different frequency bands. We estimated the alterations of local synchronization across five bands ranging from 0 to 0.25 Hz. Seventy-nine children with TS and 63 age-, sex-, and handedness-matched healthy children were recruited. Frequency-specific regional homogeneity (ReHo) and independent component analysis were used to identify functional alterations between TS and healthy children. TS patients showed significantly increased ReHo in the left precentral gyrus and decreased ReHo in the right operculum. Abnormal ReHo alterations of the superior frontal gyrus, superior parietal gyrus, anterior cingulate gyrus, putamen, superior temporal gyrus, and operculum were observed in different frequency bands. TS patients showed increased connectivity of the right superior frontal gyrus within the left executive control network. In addition, a significantly negative correlation was found between Yale Global Tic Severity Scale (YGTSS) vocal score and ReHo values of the right operculum in the highest frequency bands (0.198-0.25 Hz), while a significant positive correlation was found between YGTSS motor score and altered connectivity of the right superior frontal gyrus. The present study revealed frequency-specific abnormal alterations of ReHo in the whole brain and altered connectivity within the executive control network of TS children. Its neural importance and clinical practicability require further investigation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2020 Lou, Li, Wang, Ji, Zang, Wang and Feng.)
Databáze:	MEDLINE
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