| Autor: |
Tsuda M; Center for Advanced Marine Core Research, Kochi University.; Department of Agriculture and Marine Science, Kochi University., Akakabe M; Science Research Center, Kochi University., Minamida M; Department of Applied Science, Kochi University., Kumagai K; Science Research Center, Kochi University., Tsuda M; Science Research Center, Kochi University., Konishi Y; Science Research Center, Kochi University., Tominaga A; Graduate School of Kuroshio Science and Kochi Medical School, Kochi University., Fukushi E; Research Faculty of Agriculture, Hokkaido University., Kawabata J; Research Faculty of Agriculture, Hokkaido University. |
| Abstrakt: |
Two highly potent cytotoxic 26-membered macrolides, isocaribenolide-I (1) and a chlorohydrin 2, together with known amphidinolide N (3), have been isolated from a free-swimming dinoflagellate Amphidinium species (KCA09053 and KCA09056 strains) collected off Iriomote Island, Japan. The structures of 1 and 2 were determined to be a congener of 3 with an isobutyl terminus and the chlorohydrin form of 3, respectively, by detailed analyses of spectroscopic data. The relative stereochemistries of 1 and 2 were elucidated by the conformational analyses based on NMR data. |
