Phytobiological-facilitated Production of Silver Nanoparticles From Selected Non-cultivated Vegetables in Nigeria and Their Biological Potential.

Autor: Bello OM; University of Ilorin, Department of Chemistry, Ilorin, Kwara State, Nigeria., Oguntoye OS; University of Ilorin, Department of Chemistry, Ilorin, Kwara State, Nigeria., Dada AO; University of Ilorin, Department of Crop Protection, Ilorin, Kwara State, Nigeria., Bello OE; Landmark University Nanotechnology Laboratory, Department of Physical Sciences, Industrial Chemistry Programme, Omu Aran, Kwara State, Nigeria., Ali T; Federal University Dutsin-Ma, Department of Applied Chemistry, Dutsin-Ma, Katsina State, Nigeria., Alhaji AA; Federal University Dutsin-Ma, Department of Applied Chemistry, Dutsin-Ma, Katsina State, Nigeria., Adeniyi O; Federal University Dutsin-Ma, Department of Applied Chemistry, Dutsin-Ma, Katsina State, Nigeria.
Jazyk: angličtina
Zdroj: Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2020 Dec 23; Vol. 17 (6), pp. 599-609.
DOI: 10.4274/tjps.galenos.2019.10846
Abstrakt: Objectives: Plant-mediated synthesis [silver (Ag) to form Ag nanoparticles (AgNPs)] is becoming progressively well accepted in many scientific and pharmaceutical fields. The aim of this study was to synthesize AgNPs using air-dried leaves of four neglected vegetables, i.e. Ceratotheca sesamoides, Ceiba pentandra, Crassocephalum crepidioides , and Launaea taraxacifolia .
Materials and Methods: Ultraviolet-visible (UV-Vis) spectroscopy, fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) were used for characterization. Cell stabilization membrane and lipoxidase assays were used to determine used to assess the antiinflammatory activities while 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS+) assays were used to assess the antioxidant activities of AgNPs [ L. taraxacifolia -AgNPs, C. sesamoides Ag nanoparticles (CS-AgNPs), C. pentandra Ag nanoparticles (CP-AgNPs), and C. crepidioides AgNPs (CC-AgNPs)].
Results: The UV-Vis spectra of the synthesized NPs displayed absorption bands at around 360-440 nm, which is a characteristic band for AgNPs. The SEM image showed that the AgNPs formed were spherical in morphology. CC-AgNPs exhibited the most significant inhibitory activity against human red blood cell membrane stabilizasyonu [median inhibitory concentration (IC 50 ): 32.2 μg/mL] while CS-AgNPs displayed the most significant inhibitory activity against lipoxygenases (IC 50 : 32.8 μg/mL). CP-AgNPs exhibited the most significant antioxidant effect against both ABTS and DPPH (IC 50 : 5.5 and 6.4 μg/mL) when compared to ascorbic acid (IC 50 : 4.7 μg/mL).
Conclusion: The synthesized AgNPs were found to be stable and the FTIR evidence suggested that the phytochemicals in the vegetables might have played an important role in the reduction and stabilization of AgNPs. This work showed that the synthesized AgNPs from non-cultivated vegetables can find relevance and application in health, drugs, food and environmental science. The evidences herein further confirmed their ethnopharmacological applications.
Databáze: MEDLINE