Distribution and morphology of calbindin neurons in the Amygdaloid Complex of the marmoset monkey (callithrix jacchus).

Autor: de Góis Morais PLA; Universidade do Estado do Rio Grande do Norte, Brazil. Electronic address: Pauloleonardo87@hotmail.com., Paiva KM; Universidade do Estado do Rio Grande do Norte, Brazil., Oliveira RF; Universidade do Estado do Rio Grande do Norte, Brazil., Santana MAD; Universidade Federal do Vale do São Francisco, Brazil., Guzen FP; Universidade do Estado do Rio Grande do Norte, Brazil., Engelberth RCGJ; Universidade Federal do Rio Grande do Norte, Brazil., de Souza Cavalcante J; Universidade Federal do Rio Grande do Norte, Brazil., Nascimento ES Junior; Universidade Federal do Rio Grande do Norte, Brazil., Cavalcanti JRLP; Universidade do Estado do Rio Grande do Norte, Brazil.
Jazyk: angličtina
Zdroj: Journal of chemical neuroanatomy [J Chem Neuroanat] 2021 Mar; Vol. 112, pp. 101914. Date of Electronic Publication: 2020 Dec 31.
DOI: 10.1016/j.jchemneu.2020.101914
Abstrakt: The location and distribution of the calcium-binding protein calbindin-D28k (CB) has been considered to be of great value as a neuronal marker for identifying distinct brain regions and discrete neuronal populations. In the amygdaloid complex (AC), the balance of excitatory and inhibitory inputs is controlled by CB immunoreactive interneurons. Alterations of inhibitory mechanisms in the AC may play a role in the emotional symptomatology of neurological diseases like Alzheimer's and psychiatric disorders like posttraumatic stress disorder. The present investigation examined the distribution and morphology of CB-containing neurons, neuropils and fibers in marmoset monkey ACs by using immunohistochemical and morphometrical methods. We recognized four types of CB cells in the AC: type 1 (multipolar), type 2 (spherical or bipolar), type 3 (pyramidal) and type 4 (halo cells), a cell type specific to the marmoset located in the basal and central nuclei. We detected CB cells in all nuclei and areas of the AC, where most of the cells were present in the deep nuclei (lateral, basal, accessory basal and paralaminar). In the superficial nuclei (the nucleus of the lateral olfactory tract, medial nucleus, periamygdaloid cortex and cortical nuclei), the CB cells were abundant in layers 2 and 3. The intercalated nuclei contained small densely packed cells. The CB neuropils were particularly dense in layer 1 of the superficial nuclei, in the deep nuclei and in the amygdalohippocampal area. Large CB immunoreactive neurons in the white matter and fibers with varicosities were found in the myelin tracts that surrounded the AC. These findings are the first step in determining whether some of these cells are specifically disrupted in pathological states.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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