Effect of isotretinoin on induced tooth movement in rats.

Autor: Graciano Parra AX; Postgraduate Program in Dentistry, Orthodontics, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil. Electronic address: aline.johann@pucpr.br., Batista Rodrigues Johann AC; Postgraduate Program in Dentistry, Stomatology and Biosciences, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil., Trindade Grégio Hardy AM; Department of Physiology and Pharmacology, The University of Toledo, College of Medicine &Life Sciences, Toledo, OH., Oppitz LR; Postgraduate Program in Dentistry, Orthodontics, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil., Araujo CM; Postgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, Paraná, Brazil., Tanaka OM; Postgraduate Program in Dentistry, Orthodontics, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil., Guariza Filho O; Postgraduate Program in Dentistry, Orthodontics, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil., Camargo ES; Postgraduate Program in Dentistry, Orthodontics, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil.
Jazyk: angličtina
Zdroj: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics [Am J Orthod Dentofacial Orthop] 2021 Feb; Vol. 159 (2), pp. 193-201. Date of Electronic Publication: 2020 Dec 31.
DOI: 10.1016/j.ajodo.2019.12.022
Abstrakt: Introduction: This study was performed to evaluate the effect of isotretinoin on tooth displacement and tissues related to induced tooth movement (ITM) in rats.
Methods: Wistar rats were randomly divided into 4 groups: vegetable oil (O; n = 40), 7.5 mg/kg isotretinoin (I; n = 40), vegetable oil + ITM (OM; n = 44), and 7.5 mg/kg isotretinoin and ITM (IM; n = 39). After the daily application of the solutions for 30 days, an orthodontic appliance was installed to mesially displace the maxillary first right molar (30 cN) of rats in the OM and IM groups. The animals were killed 2, 7, 14, or 21 days after placement of the devices. The animals in the O and I groups did not undergo ITM but were killed simultaneously. The animals were examined for tooth displacement, the neoformation of mature collagen, bone and root resorption, the presence of hyalinized areas, and trabecular bone modeling by microcomputed tomography.
Results: There was no difference in tooth displacement, the number of osteoclasts, the presence of hyalinized areas, or trabecular bone among the O, I, OM, and IM groups across the periods tested (P >0.05). A lower percentage of mature collagen was found in the IM group than in the OM group on day 7 (P <0.05). A lower frequency of root resorption was found in the IM group than in the OM group on days 2 and 21 (P <0.05).
Conclusions: Isotretinoin at 7.5 mg/kg decreased root resorption in rats subjected to ITM.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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