Altered brain creatine cycle metabolites in bipolar I disorder with childhood abuse: A 1 H magnetic resonance spectroscopy study.

Autor: Bio DS; Mood Disorders Unit (PROGRUDA), Department of Psychiatry, School of Medicine, University of São Paulo, Brazil., Moreno RA; Mood Disorders Unit (PROGRUDA), Department of Psychiatry, School of Medicine, University of São Paulo, Brazil., Garcia-Otaduy MC; Institute of Radiology (InRAD), Department of Radiology, School of Medicine, University of São Paulo, Brazil., Nery F; University of Cincinnati Medical Center, United States., Lafer B; Bipolar Disorders Program (PROMAN), Department of Psychiatry, School of Medicine, University of São Paulo, Brazil., Soeiro-de-Souza MG; Department of Psychiatry, School of Medicine, University of São Paulo, Brazil. Electronic address: mgss@usp.br.
Jazyk: angličtina
Zdroj: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2021 Jul 13; Vol. 109, pp. 110233. Date of Electronic Publication: 2020 Dec 30.
DOI: 10.1016/j.pnpbp.2020.110233
Abstrakt: Background: Childhood abuse (CA) is a risk factor for a number of psychiatric disorders and has been associated with higher risk of developing bipolar disorders (BD). CA in BD has been associated with more severe clinical outcomes, but the neurobiological explanation for this is unknown. Few studies have explored in vivo measurement of brain metabolites using proton magnetic resonance spectroscopy ( 1 H-MRS) in CA and no studies have investigated the association of CA severity with brain neurometabolites in BD.
Objective: To investigate whether CA severity is associated with changes in anterior cingulate cortex (ACC) neurometabolite profile in BD and HC subjects.
Methods: Fifty-nine BD I euthymic patients and fifty-nine HC subjects were assessed using the Childhood Trauma Questionnaire (CTQ) and underwent a 3-Tesla 1 H-MRS scan. Severity of childhood abuse (physical, sexual and emotional) and its association with levels of brain metabolites was analyzed within each group.
Results: BD patients had higher total scores on the CTQ and higher severity rates of sexual and physical abuse compared to HC subjects. Greater severity of physical and sexual abuse was associated with increased ACC PCr level and lower Cr/PCr ratio in the BD group only.
Conclusion: Sexual and physical abuse in BD patients, but not in HC subjects, appeared to be associated with creatine metabolism in the ACC, which can influence neuronal mitochondrial energy production. Further studies should investigate whether this is the mechanism underlying the association between CA and worse clinical outcomes in BD.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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