Long-term intradialytic hybrid exercise training on fatigue symptoms in patients receiving hemodialysis therapy.

Autor: Grigoriou SS; Live Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece., Krase AA; Live Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece., Karatzaferi C; Live Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece., Giannaki CD; Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus., Lavdas E; Department of Biomedical Sciences, University of West Attica, Athens, Greece., Mitrou GI; Live Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece., Bloxham S; School of Sports, Health and Wellbeing, Plymouth Marjon Univeristy, Plymouth, UK., Stefanidis I; School of Health Science, Department of Medicine, University of Thessaly, Larissa, Greece., Sakkas GK; Live Lab, Department of PE and Sport Science, University of Thessaly, 42100, Trikala, Greece. gsakkas@uth.gr.; School of Sports and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. gsakkas@uth.gr.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2021 Apr; Vol. 53 (4), pp. 771-784. Date of Electronic Publication: 2021 Jan 02.
DOI: 10.1007/s11255-020-02711-8
Abstrakt: Purpose: Hemodialysis (HD) patients suffer from generalized weakness, exercise intolerance and muscle atrophy, all leading to generalized fatigue and lack of energy. HD patients spend at least 50% of their time in a functionally "switch off" mode with their fatigue sensations reaching a peak in the immediate hours after the dialysis session. The purpose of the current study was to assess the effectiveness of a nine-month hybrid intradialytic exercise program on fatigue symptoms occurring during and after hemodialysis session.
Methods: Twenty stable hemodialysis patients were included in the study (59 ± 13.7 years; 16 males). All patients completed a 9-month supervised exercise training program composed of both aerobic cycling and resistance training during HD. Aspects related to physical and generalized fatigue were assessed via validated questionnaires, while physical performance was assessed by a battery of tests, before and after the intervention period.
Results: Exercise capacity and physical performance were increased by an average of 65 and 40%, respectively. Patients reported feeling better during post-dialysis hours in question 1 (p = 0.000), question 3 (p = 0.009) and question 4 (p = 0.003) after the 9-month intervention. In addition, exercise training improved scores in cognitive function (p = 0.037), vitality (p = 0.05), depression (p = 0.000) and fatigue (p = 0.039).
Conclusion: The present study showed that a 9-month hybrid (aerobic + resistance) exercise training program improved symptoms of post-dialysis fatigue and overall general perception of fatigue. Hybrid exercise training is a safe and effective non-pharmacological approach to ameliorate fatigue symptoms in HD patients.
Trial Registration Number: Trial registration number The study is registered at ClinicalTrials.gov (NCT01721551, 2012) as a clinical trial.
Databáze: MEDLINE
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