Synthesis of novel nicotinamide susbstituted phthalocyanine and photodynamic antomicrobial chemotherapy evaluation potentiated by potassium iodide against the gram positive S. aureus and gram negative E. coli.

Autor: Ullah A; State Key Laboratory of Solidification Processing, Shaanxi Engineering Laboratory for Graphene New Carbon Materials & Application, School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China.; NCP-NPU Joint International Research Center on Advanced Nanomaterials and Defects Engineering School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China., Zhao T; State Key Laboratory of Solidification Processing, Shaanxi Engineering Laboratory for Graphene New Carbon Materials & Application, School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China. ztk@nwpu.edu.cn.; NCP-NPU Joint International Research Center on Advanced Nanomaterials and Defects Engineering School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China. ztk@nwpu.edu.cn., Muhammad MT; Fujian Institute of Research On Structure of Matter CAS, 155 Yang Qiao West road, Fuzhou, Fujian, 350002, People's Republic of China., Khan M; State Key Laboratory of Solidification Processing, Shaanxi Engineering Laboratory for Graphene New Carbon Materials & Application, School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China. mkhanchemistry@yahoo.com.; NCP-NPU Joint International Research Center on Advanced Nanomaterials and Defects Engineering School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China. mkhanchemistry@yahoo.com.; Department of Chemistry, University of Okara, Punjab, Pakistan. mkhanchemistry@yahoo.com., Qurban S; Shanghai Institute of Orgnaic Chemistry CAS, 345 Linglin Road, Shanghai, 200032, People's Republic of China., Rahman A; Department of Chemistry and Chemical Engineering, Guangzhou University, Guanzhuo, 510006, People's Republic of China., Ahmad I; NCP-NPU Joint International Research Center on Advanced Nanomaterials and Defects Engineering School of Material Science and Engineering, Northwestern Polytechnical University, Xian, 710072, Shaanxi, People's Republic of China.
Jazyk: angličtina
Zdroj: Biotechnology letters [Biotechnol Lett] 2021 Apr; Vol. 43 (4), pp. 781-790. Date of Electronic Publication: 2021 Jan 02.
DOI: 10.1007/s10529-020-03071-0
Abstrakt: In the present work, we propose the synthesis of novel nicotinamide subsituted phthlocyanine photosensitizer (PS) and characterized by FTIR, UV-visible, H-NMR and MALDI Toff spectroscopy. Nicotinamide plays a vital rule in the central nervous system and its potential as a therapeutic for neurodegenerative disease. Nicotinamide substituted PS (3) efficiently produced ROS via type-1 process as measured by DCF assay. We observed that our PS after red light illumination (22 J/cm 2 ) killed gram positive S. aureus upto 3 log reduction. Furher the addition of Potassium Iodide (100 mM) significantly potentiated PS at lower concentrations and enhanced the bacterial killing upto 6 log reduction against the S. aureus. We further found that the synergistic effect of PS and KI also eradicated the gram negative E. coli strain at lower concentraion of PS and found to killed E. coli upto 5 log reduction under the red light illumination at 22 J/cm 2 of light dose. The conjugation of such biologically important form of vitamin B 3 with PS would be a great addition and could pav the way for the novel photodynamic agent in the treatement of cancer and infectious diseases. A new symmetrical Nicotinamide tetrasubstituted zinc phthalocyanine (3) was synthesized. Upon addition of potassium Iodide with PS, the PS exhibited significant photodynamic activity with 5-6 logs reduction in bacterial load was achieved.
Databáze: MEDLINE
Externí odkaz: