Safety and efficacy of bilateral simultaneous XEN implant surgery: a pilot study.

Autor: Urcola A; Hospital Universitario Araba, Olaguibel, 29, Vitoria-Gasteiz, Spain. jaurcola@gmail.com.; Universidad del País Vasco-Euskal Herriko Unibertsitatea, Vitoria-Gasteiz, Spain. jaurcola@gmail.com.; Grupo Oftalmobiología Experimental, Universidad del País Vasco-Euskal Herriko Unibertsitatea, Leioa, Spain. jaurcola@gmail.com., Garay-Aramburu G; Hospital Universitario Araba, Olaguibel, 29, Vitoria-Gasteiz, Spain.; Universidad del País Vasco-Euskal Herriko Unibertsitatea, Vitoria-Gasteiz, Spain.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2021 Mar; Vol. 41 (3), pp. 859-866. Date of Electronic Publication: 2021 Jan 02.
DOI: 10.1007/s10792-020-01640-w
Abstrakt: Objective: To evaluate the efficacy and safety of the bilateral simultaneous XEN (BISIXEN) surgery in open-angle glaucoma patients.
Methods: Retrospective analysis of a prospective data base conducted on uncontrolled glaucoma patients who underwent BISIXEN surgery. Primary endpoint measure was the incidence of sight-threatening complications. Secondary endpoints included intraocular pressure (IOP) reduction and in number of required antiglaucoma medications.
Results: Ten patients (20 eyes) were included in the analysis. Median (95% confidence interval) follow-up was 12.0 (7.0-12.0) months, with 14 eyes having a follow-up of 12 months. No sight-threatening complications, such as endophthalmitis, retinal detachment, corneal decompensation, or intraocular hemorrhages were observed in any eye of study sample. Mean IOP decreased significantly from 25.2 (21.5-28.9) mm Hg at baseline to 15.1 (13.4-16.8) mm Hg at the last follow-up visit (p = 0.0001). Mean number of antiglaucoma medications was significantly reduced from 2.9 (2.5 to 3.3) drugs at baseline to 0.40 (0.00-0.70) at the end of the study (p < 0.0001). At the last study visit, 14 (70.0%) eyes had an IOP ≥ 6 and ≤ 18 mm Hg without treatment. Two eyes needed surgical revision and three ones needed a new glaucoma surgery: two underwent Ahmed valves (one eye with aniridia and the other previously operated on) and one underwent non-penetrating deep sclerectomy.
Conclusions: Bilateral simultaneous XEN implantation may be a feasible strategy in those patients with high anesthetic risk.
Databáze: MEDLINE
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