| Autor: |
Loeb C; Institute of Neurology, University of Genova, Italy., Marinari UM, Benassi E, Besio G, Cottalasso D, Cupello A, Maffini M, Mainardi P, Pronzato MA, Scotto PA |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental neurology [Exp Neurol] 1988 Feb; Vol. 99 (2), pp. 440-6. |
| DOI: |
10.1016/0014-4886(88)90160-4 |
| Abstrakt: |
A sonicated liposome suspension of gamma-aminobutyric acid (GABA) and phosphatidylserine (liposome-entrapped GABA), intraperitoneally administered in rats, inhibited EEG epileptic activity induced by penicillin, whereas GABA did not. A significant increase (20.4%) in brain radioactivity accumulation occurred at 5 min after i.p. administration of [14C]GABA associated with phosphatidylserine in comparison with the administration of [14C]GABA; such an increase persisted after 20 min. However, the accumulation of radioactivity into brain synaptosomes demonstrated a 24.1% increase at 5 min and subsequently showed a 43.3% increase at 20 min after injection of liposome-entrapped GABA. The above findings suggest that phosphatidylserine stimulates exogenous GABA uptake into brain GABAergic nerve terminals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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