Relationship between expression mRNA gene Treg, Treg, CD4 + , and CD8 + protein levels with TST in tuberculosis children: A nested case-control.

Autor:	Farsida; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Indonesia., Shabariah R; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Indonesia., Hatta M; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Patellongi I; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Prihantono; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Nasrum Massi M; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Asadul Islam A; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Natzir R; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Dwi Bahagia Febriani A; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Hamid F; Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia., Fatimah; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Indonesia., Akaputra R; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Indonesia., Aprilia Savitri P; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Indonesia.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2020 Dec 19; Vol. 61, pp. 44-47. Date of Electronic Publication: 2020 Dec 19 (Print Publication: 2021).
DOI:	10.1016/j.amsu.2020.12.011
Abstrakt:	Background: The ability of Mycobacterium tuberculosis to survive intracellularly, provides a cellular adaptive immune response played by specific T cells to defend against tuberculosis. The adaptive immune response to Bacillus of Calmette and Guerin (BCG) immunization is responded to by B cells, T Follicular B helper, T regulatory, restriction CD1, CD8 + , CD4 + , Th1, Th2, and Th17. BCG immunization can cause a tuberculin test reaction to being positive. The tuberculin test is a method for diagnosing TB infection and for screening individuals for latent infection and assessing the rate of TB infection in a given population. Methods: a nested case-control survey was conducted on patients with a diagnosis of TB and parents 0-18 years of age from 3 hospitals in Indonesia during September-November 2019 with a total sample of 69 people undergoing clinical examinations, supporting and diagnosing subjects, blood sampling 1-2 cc for examination mRNA gene Treg, Treg, CD 4+, and CD 8+, then centrifuged at 3000 rpm for 10 min to support blood cells and serum. Results: There was a significant relationship between expression of mRNA gene Treg with TST (p = 0,000), Treg with TST (p = 0,000), and CD4 + with TST (p = 0,000). Meanwhile, CD8 + was not significantly associated with TST (p = 0.118). Conclusions: It is necessary to check the expression of mRNA gene Treg, Treg, CD4 + , and CD8 + with more samples to find the mean value that shows the protective value of further TB. (© 2020 The Author(s).)
Databáze:	MEDLINE
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