Frequency of Three-Vessel Disease Among Patients With Non-ST Segment Elevation Myocardial Infarction.

Autor:	Ahmed F; Cardiology, Dow University of Health Sciences, Civil Hospital Karachi, Karachi, PAK., Khan MS; Internal Medicine, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, PAK., Ali Shah SD; Cardiology, Dow University of Health Sciences, Civil Hospital Karachi, Karachi, PAK., Jalbani J; Interventional Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK., Ali Shah A; Cardiology, Dow University of Health Sciences, Civil Hospital Karachi, Karachi, PAK., Shaikh GA; Cardiology, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2020 Nov 22; Vol. 12 (11), pp. e11634. Date of Electronic Publication: 2020 Nov 22.
DOI:	10.7759/cureus.11634
Abstrakt:	Background: Though the presence of three-vessel disease (3VD) among patients with non-ST Segment Elevation Myocardial Infarction (NSTEMI) is relatively common, very limited data is available regarding its clinical significance. The current study aimed to determine the frequency of 3VD among NSTEMI patients presenting at the tertiary care hospital of Karachi, Pakistan. Methodology: This cross-sectional study was conducted at the National Institute of Cardiovascular Diseases, Karachi from August 15 2015 to February 15 2016 over a sample of 139 NSTEMI patients. Data regarding patients' baseline characteristics were recorded in a proforma. Coronary angiography was performed to determine the presence of 3VD. The frequency of occluded arteries and 3VD was also recorded and the collected data was then analyzed using Statistical Package for Social Sciences (SPSS) version 20.0 (IBM Corp., Armonk, NY, USA). Results: A total of 139 NSTEMI patients were enrolled in the study with a mean age of 50.47 ± 12.47 years. The majority of them were males (70.5%), mostly ≥ 40 years of age (67.6%). Among the comorbidities, 50.4% of patients had diabetes mellitus (DM), 61.9% were hypertensive and 30.9% had dyslipidemia. The overall frequency of 3VD among the enrolled NSTEMI patients was 30.2%. Three major arteries were found to be occluded; 68.3% NSTEMI patients had occlusion in the left anterior descending (LAD) artery, followed by right coronary artery (RCA) among 49.6%, 40.3% had left circumflex (LCX) artery occlusion, and 50.4% had diagonal and obtuse marginal (OM) artery occlusion respectively. Among the effect modifiers, no significant impact of age, gender, and smoking habits was observed on the frequency of 3VD among NSTEMI patients (p > 0.05). Among the reported comorbidities, DM was significant among NSTEMI patients with 3VD (p < 0.05). Conclusion: Our study results indicated that a significant proportion of NSTEMI patients had 3VD, independent of the effect of age and gender. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2020, Ahmed et al.)
Databáze:	MEDLINE
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