| Autor: |
Tverdokhlebova TS; Laboratory of Hybrid Plasma Systems, Tomsk Polytechnic University, Tomsk 634050, Russia., Antipina LS; Department of Hospital Surgery with the Course of Cardiovascular Surgery, Siberian State Medical University, Tomsk 634050, Russia., Kudryavtseva VL; Laboratory of Hybrid Plasma Systems, Tomsk Polytechnic University, Tomsk 634050, Russia.; School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK., Stankevich KS; Laboratory of Hybrid Plasma Systems, Tomsk Polytechnic University, Tomsk 634050, Russia.; Department of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA., Kolesnik IM; Laboratory of Hybrid Plasma Systems, Tomsk Polytechnic University, Tomsk 634050, Russia., Senokosova EA; Division of Experimental and Clinical Cardiology, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia., Velikanova EA; Division of Experimental and Clinical Cardiology, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia., Antonova LV; Division of Experimental and Clinical Cardiology, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia., Vasilchenko DV; Department of Hospital Surgery with the Course of Cardiovascular Surgery, Siberian State Medical University, Tomsk 634050, Russia., Dambaev GT; Department of Hospital Surgery with the Course of Cardiovascular Surgery, Siberian State Medical University, Tomsk 634050, Russia., Plotnikov EV; Laboratory of Hybrid Plasma Systems, Tomsk Polytechnic University, Tomsk 634050, Russia., Bouznik VM; Arctic Climate Materials Division, All Russian Scientific Research Institute of Aviation Materials, Moscow 105005, Russia.; Department of Inorganic Chemistry, Tomsk State University, Tomsk 634050, Russia., Bolbasov EN; Laboratory of Hybrid Plasma Systems, Tomsk Polytechnic University, Tomsk 634050, Russia. |
| Abstrakt: |
Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF-TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF-TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF-TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds. |
