[Morphological changes in pulmonary alveolus macrophages as affected by alcohol and nitrosodimethylamine].

Autor: Fetisov VV, Gasimova ZM, Litvinov LN, Baldaeva LL
Jazyk: ruština
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1988 Jan; Vol. 105 (1), pp. 97-100.
Abstrakt: Comparative electron microscopic studies of lung alveolar macrophage (LAM) ultrastructure (with their surface architectonics) were performed in transmission and scan regimen in 3 groups of animals: in intact rats and in rats 12 and 24 hours after a single intragastric administration of nitrosodimethylamine at a concentration of 30 mg/kg in one case and of 50% ethanol (2 ml per 100 g animal weight) in the other case. The transformation of cytoplasmic excrescences, manifested in their diminution, twisting and fusion resulted in the formation of fold-hilly LAM surface. The data obtained may be used for the elaboration of criteria for the assessment of environmental effects of toxic factors.
Databáze: MEDLINE