[Possibilities of using sildenafil in patients with cardiovascular comorbidities who underwent transurethral resection of the prostate].

Autor:	Neymark AI; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia., Neymark BA; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia., Davydov AV; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia., Nozdrachev NA; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia., Kablova IV; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia., Yakovets YV; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia., Levin VP; Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO 'Altai State Medical University' of the Ministry of Health of Russia, Barnaul, Russia.
Jazyk:	ruština
Zdroj:	Urologiia (Moscow, Russia : 1999) [Urologiia] 2020 Dec (6), pp. 38-43.
Abstrakt:	Aim: To study the efficacy and safety of using sildenafil in patients with erectile dysfunction (ED) and concomitant cardiovascular diseases (CVD) who underwent transurethral resection of the prostate (TURP). Material and Methods: A total of 59 patients (age from 50 to 75 years) with a diagnosis of benign prostatic hyperplasia (BPH), requiring surgical treatment due to inefficiency of drug therapy, I-PSS score more than 20 points), who were sexually active, but had erectile dysfunction (IIEF score < 21), coronary heart disease (NYHA class I) and stage 1-2 hypertension with stable blood pressure. All patients underwent bipolar TURP. From the first day after the TURP, therapy was prescribed as following: tamsulosin 0.4 mg once a day for 90 days, ciprofloxacin 500 mg twice a day for 10 days. In addition, the patients received treatment for comorbidities. In the main group (n=30), men additionally received sildenafil (EFFEX Sildenafil Evalar) 50 mg daily for 60 days, starting from the 30th day postoperatively. We have chosen this drug from an economic standpoint. Results: At baseline, all patients in both groups had hemodynamic and microcirculatory disorders in the prostate, which got worse in the early postoperative period. During the long-term follow-up, hemodynamic and microcirculatory impairments decreased. This effect was more pronounced in patients who received sildenafil. In addition, patients had an improvement in sexual function. During follow-up, there was no adverse effects of sildenafil on hemodynamic parameters (blood pressure, heart rate). Conclusion: Our results allow to recommend sildenafil in order to restore sexual function postoperatively in patients with BPH, including those with concomitant cardiovascular disorders.
Databáze:	MEDLINE
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