| Autor: |
Njoroge MM; 1Med Biotech Laboratories, Kampala, Uganda., Irungu Mwangi V; 2Institute of Primate Research, Nairobi, Kenya., Owalla TJ; 1Med Biotech Laboratories, Kampala, Uganda., Ozwara H; 2Institute of Primate Research, Nairobi, Kenya., Egwang TG; 1Med Biotech Laboratories, Kampala, Uganda. |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2020 Dec 29; Vol. 104 (3), pp. 993-995. Date of Electronic Publication: 2020 Dec 29. |
| DOI: |
10.4269/ajtmh.20-0206 |
| Abstrakt: |
Intranasal instillation of SE36, a malaria vaccine candidate antigen, in lactating BALB/c strain (derived from the Bagg and albino laboratory inbred mice) female mice resulted in the appearance of the antigen in breast milk as demonstrated by sandwich ELISA and Western blot. Pups born of immunologically naive mice and breastfed on lactating foster mothers exposed intranasally to SE36 developed IgG anti-SE36 antibodies. These data demonstrate that maternal immunization in mice by this route in lactating mothers can result in active immunization of offspring via ingestion of breast milk containing antigen. If confirmed in a nonhuman primate model and in human subjects, this strategy might be transformative for vaccination against malaria and other infant killer infectious diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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