The Outcome of Fungal Pneumonia with Hematological Cancer.
| Autor: | Eren E; Kayseri City Hospital, Infectious Disease Clinic, Kayseri, Turkey. esmaereneryilmaz@gmail.com., Alp E; Ministry of Health, Ankara, Turkey., Cevahir F; Unıversıty of Sakarya Applıed Scıences, Akyazı Vocational School of Health Services, Medical Services and Techniques Department, Sakarya, Turkey., Tok T; Erciyes University, Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Kayseri, Turkey., Kılıç AU; Erciyes University, Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Kayseri, Turkey., Kaynar L; Erciyes University, Faculty of Medicine, Department of Internal Medicine, Hematology, Kayseri, Turkey., Yüksel RC; Kayseri City Hospital, Intensive Care Unit, Kayseri, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Infection & chemotherapy [Infect Chemother] 2020 Dec; Vol. 52 (4), pp. 530-538. |
| DOI: | 10.3947/ic.2020.52.4.530 |
| Abstrakt: | Background: Fungal pneumonia is a common infectious complication of hematological cancer (HC) patients. In this retrospective study, the objective was set to identify the risk factors and outcome of fungal pneumonia in adult HC patients. Materials and Methods: This retrospective study was conducted with adult (>16 years) HC patients from January 2017 and December 2018. Results: During the study period, of 181 patients included 76 were diagnosed with fungal pneumonia. The most common HC was identified as acute myeloid leukaemia (40%). Of the participating patients, 52 (29%) were hematopoietic stem cell transplant (HSCT) recipients. The median age of patients with fungal pneumonia was significantly greater: 57 vs. 48 (odds ratio [OR]: 1.08) and they had longer hospitalization durations (OR: 1.14). Overall, 37 patients (20%) died, and 28-day mortality was significantly greater among patients with fungal pneumonia than without fungal pneumonia (33% vs. 11%). The most significant risk factors for mortality in fungal pneumonia were identified as need of intensive care unit (ICU) (OR: 191.2, P <0.001) and the need of vasopressor support (OR:81.6, P <0.012). ICU-mortality was (88%). Conclusion: Fungal pneumonia is a lethal complication in HC patients. Intensive care need is the most important predictive factor for mortality. Competing Interests: No conflicts of interest. (Copyright © 2020 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, and The Korean Society for AIDS.) |
| Databáze: | MEDLINE |
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