Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth.

Autor:	Chen D; Potocsnak Family Division of Adolescent and Young Adult Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Department of Psychiatry & Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Strang JF; Division of Neuropsychology, Children's National Medical Center, Washington, District of Columbia, USA.; Center for Neuroscience, Children's Research Institute, Children's National Medical Center, Washington, District of Columbia, USA.; Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia, USA.; Department of Neurology, George Washington University School of Medicine, Washington, District of Columbia, USA.; Department of Psychiatry, George Washington University School of Medicine, Washington, District of Columbia, USA., Kolbuck VD; Potocsnak Family Division of Adolescent and Young Adult Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Rosenthal SM; Division of Endocrinology, Benioff Children's Hospital, University of California San Francisco, San Francisco, California, USA., Wallen K; Department of Psychology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA., Waber DP; Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA., Steinberg L; Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA., Sisk CL; Department of Psychology, Michigan State University, East Lansing, Michigan, USA., Ross J; Nemours duPont Hospital for Children, Wilmington, Delaware, USA.; Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Paus T; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Department of Personality, Psychological Assessment and Treatment, University of Deusto, Bilbao, Spain., McCarthy MM; Program in Neuroscience, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Micevych PE; David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Martin CL; School of Social and Family Dynamics, Arizona State University, Tempe, Arizona, USA., Kreukels BPC; Amsterdam UMC, Location VUmc, Department of Medical Psychology and Center of Expertise on Gender Dysphoria, Amsterdam, The Netherlands., Kenworthy L; Division of Neuropsychology, Children's National Medical Center, Washington, District of Columbia, USA.; Center for Neuroscience, Children's Research Institute, Children's National Medical Center, Washington, District of Columbia, USA.; Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia, USA.; Department of Neurology, George Washington University School of Medicine, Washington, District of Columbia, USA.; Department of Psychiatry, George Washington University School of Medicine, Washington, District of Columbia, USA., Herting MM; Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA.; Department of Pediatrics, University of Southern California, Los Angeles, California, USA., Herlitz A; Section of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Haraldsen IRJH; Centre for Cognitive Health in Brain Disease, Oslo University Hospital, Oslo, Norway., Dahl R; School of Public Health, University of California, Berkeley, Berkeley, California, USA., Crone EA; Department of Developmental and Educational Psychology, Brain and Development Research Center, Leiden University, Leiden, The Netherlands., Chelune GJ; Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA., Burke SM; Department of Developmental and Educational Psychology, Brain and Development Research Center, Leiden University, Leiden, The Netherlands., Berenbaum SA; Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania, USA.; Department of Pediatrics, The Pennsylvania State University, University Park, Pennsylvania, USA., Beltz AM; Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA., Bakker J; GIGA Neurosciences, Liège University, Liège, Belgium., Eliot L; Department of Neuroscience, Rosalind Franklin University of Medicine & Science, Chicago, Illinois, USA., Vilain E; Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia, USA.; Department of Genomics and Precision Medicine, George Washington University, Washington, District of Columbia, USA.; Epigenetics, Data, & Politics at Centre National de la Recherche Scientifique, Paris, France., Wallace GL; Department of Speech, Language, and Hearing Science, George Washington University, Washington, District of Columbia, USA., Nelson EE; Center for Biobehavioral Health, The Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA., Garofalo R; Potocsnak Family Division of Adolescent and Young Adult Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jazyk:	angličtina
Zdroj:	Transgender health [Transgend Health] 2020 Dec 11; Vol. 5 (4), pp. 246-257. Date of Electronic Publication: 2020 Dec 11 (Print Publication: 2020).
DOI:	10.1089/trgh.2020.0006
Abstrakt:	Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment. Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were included in the consensus parameter. Results: The Delphi procedure identified 160 initial expert recommendations, 44 of which ultimately achieved consensus. Consensus study design elements include the following: a minimum of three measurement time points, pubertal staging at baseline, statistical modeling of sex in analyses, use of analytic approaches that account for heterogeneity, and use of multiple comparison groups to minimize the limitations of any one group. Consensus study comparison groups include untreated transgender youth matched on pubertal stage, cisgender (i.e., gender congruent) youth matched on pubertal stage, and an independent sample from a large-scale youth development database. The consensus domains for assessment includes: mental health, executive function/cognitive control, and social awareness/functioning. Conclusion: An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth. Competing Interests: No competing financial interests exist. (© Diane Chen et al. 2020: Published by Mary Ann Liebert, Inc.)
Databáze:	MEDLINE
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