| Autor: |
Chatzileontiadou DSM; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Sloane H; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Nguyen AT; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Gras S; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia., Grant EJ; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. |
| Abstrakt: |
As a major arm of the cellular immune response, CD4 + T cells are important in the control and clearance of infections. Primarily described as helpers, CD4 + T cells play an integral role in the development and activation of B cells and CD8 + T cells. CD4 + T cells are incredibly heterogeneous, and can be divided into six main lineages based on distinct profiles, namely T helper 1, 2, 17 and 22 (Th1, Th2, Th17, Th22), regulatory T cells (Treg) and T follicular helper cells (Tfh). Recent advances in structural biology have allowed for a detailed characterisation of the molecular mechanisms that drive CD4 + T cell recognition. In this review, we discuss the defining features of the main human CD4 + T cell lineages and their role in immunity, as well as their structural characteristics underlying their detection of pathogens. |
