Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine.

Autor: Pittet LF; Infectious Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia., Tebruegge M; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia; University College London Great Ormond Street Institute of Child Health, University College London, London, United Kingdom; Department of Paediatric Infectious Diseases and Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' National Health Service Foundation Trust, London, United Kingdom., Dutta B; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Louvain, Belgium., Donath S; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, Victoria, Australia., Messina N; Infectious Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia., Casalaz D; Neonatal Intensive Care Unit, Mercy Hospital for Women, Heidelberg, Victoria, Australia., Hanekom WA; Africa Health Research Institute, Durban, South Africa., Britton WJ; Centenary Institute, University of Sydney, Sydney, New South Wales, Australia., Robins-Browne R; Infectious Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Curtis N; Infectious Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: nigel.curtis@rch.org.au., Ritz N; Infectious Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia; University of Basel Children's Hospital Basel, Infectious Diseases Unit and Migrant Health Service, Basel, Switzerland; Mycobacterial Research Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2021 Jan 22; Vol. 39 (4), pp. 652-657. Date of Electronic Publication: 2020 Dec 25.
DOI: 10.1016/j.vaccine.2020.11.045
Abstrakt: Background: Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation.
Methods: Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG vaccine strains given either at birth (BCG-Denmark, BCG-Japan, or BCG-Russia) or at two months of age (BCG-Denmark).
Results: Proportions of polyfunctional CD4 + T-cells were higher in M. ulcerans-stimulated compared to unstimulated control samples. These proportions were not influenced by the vaccine strain or timing of the immunisation. The M. ulcerans-specific immune responses showed similar patterns to those observed in M. tuberculosis-stimulated samples, although they were of lower magnitude.
Conclusions: Our data show that BCG immunisation induces M. ulcerans-specific immune responses in infants, likely explaining the cross-protective effect observed in epidemiological studies. (ACTRN12608000227392).
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020. Published by Elsevier Ltd.)
Databáze: MEDLINE
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