Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading.

Autor: Gritsyna YV; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Ulanova AD; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Popova SS; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Bobylev AG; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Zhalimov VK; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia., Nemirovskaya TL; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia., Shenkman BS; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia., Vikhlyantsev IM; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. ivanvikhlyantsev@gmail.com.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2020 Nov; Vol. 495 (1), pp. 338-341. Date of Electronic Publication: 2020 Dec 25.
DOI: 10.1134/S1607672920060058
Abstrakt: The effect of HDACs 4 and 5 on the level of atrophy, calpain-1 and titin content, and TTN gene expression in rat soleus after 7-day gravitational unloading (hindlimb suspension model) was studied. The development of atrophic changes induced by gravitational unloading in rat soleus was accompanied by an increase in the calpain-1 content, an increase in titin proteolysis, and a decrease in the mRNA content of the protein. Inhibition of HDACs 4 and 5 did not eliminate the development of unloading-induced atrophy but significantly prevented proteolysis of titin and the decrease in the TTN gene expression.
Databáze: MEDLINE
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