Individualizing Time-in-Range Goals in Management of Diabetes Mellitus and Role of Insulin: Clinical Insights From a Multinational Panel.

Autor: Kalra S; Department of Endocrinology, Bharti Hospital and BRIDE, Karnal, Haryana, India. brideknl@gmail.com., Shaikh S; Department of Endocrinology, KGN Institute of Diabetes and Endocrinology, Mumbai, Maharashtra, India., Priya G; Department of Endocrinology, Fortis Hospital, Chandigarh, Punjab, India., Baruah MP; Department of Endocrinology, Excel Hospital, Guwahati, Assam, India., Verma A; Endocrine Division, Index Medical College, Indore, Madhya Pradesh, India., Das AK; Department of Endocrinology and Medicine, Pondicherry Institute of Medical Sciences, Puducherry, India., Shah M; HARMONY Endocrine Diabetes and Metabolic Clinic, Vadodara, Gujarat, India., Das S; Department of Endocrinology, Apollo Hospitals, Bhubaneswar, Odisha, India., Khandelwal D; Department of Endocrinology and Diabetes, Maharaja Agrasen Hospital, New Delhi, India., Sanyal D; Department of Endocrinology, KPC Medical College, Kolkata, West Bengal, India., Ghosh S; Department of Endocrinology and Metabolism, IPGMER, Kolkata, West Bengal, India., Saboo B; Dia Care, Diabetes Care and Hormone Clinic, Ahmedabad, Gujarat, India., Bantwal G; Department of Endocrinology, St. John's Medical College and Hospital, Bangalore, Karnataka, India., Ayyagari U; Department of Endocrinology, Apollo Sugar Clinics, Chennai, Tamil Nadu, India., Gardner D; Department of Endocrinology, Singapore General Hospital, Singapore, Singapore., Jimeno C; Department of Endocrinology, Philippine Society of Endocrinology, Diabetes and Metabolism, Manila, Philippines., Barbary NE; Department of Endocrinology, Ain Shams University, Cairo, Egypt., Hafidh KA; Department of Endocrinology, Rashid Hospital-Dubai Health Authority, Dubai, UAE., Bhattarai J; Department of Endocrinology, Metro Kathmandu Hospital, Kathmandu, Nepal., Minulj TT; Department of Endocrinology, General Hospital Karyadi, Semarang, Indonesia., Zufry H; Department of Endocrinology, General Hospital Zainoel Abidin, Aceh, Indonesia., Bulugahapitiya U; Department of Endocrinology, Colombo South Teaching Hospital, Colombo, Sri Lanka., Murad M; Department of Internal Medicine, Indira Gandhi Memorial Hospital, Malé, Maldives., Tan A; Department of Endocrinology, Sunway Medical Centre, Kuala Lumpur, Malaysia., Shahjada S; Department of Endocrinology, BSMMU (Bangabandhu Sheikh Mujib Medical University Hospital), Dhaka, Bangladesh., Bello MB; Department of Endocrinology, Gwarinpa District Hospital, Abuja, Nigeria., Katulanda P; Department of Endocrinology, University of Colombo, Colombo, Sri Lanka., Podgorski G; Department of Endocrinology, Greenacres Hospital, Port Elizabeth, South Africa., AbuHelaiqa WI; Department of Endocrinology, Hamad General Hospital, Doha, Qatar., Tan R; Department of Endocrinology, FEU-NRMF Medical Center, Quezon City, Philippines., Latheef A; Department of Endocrinology, Indira Gandhi Memorial Hospital, Malé, Maldives., Govender S; Umhlanga Centre for Diabetes Endocrinology, Durban, South Africa., Assaad-Khalil SH; Department of Endocrinology, Alexandria University, Alexandria, Egypt., Kootin-Sanwu C; Department of Endocrinology, Ridge Hospital Accra, Accra, Ghana., Joshi A; Department of Endocrinology, Kathmandu Diabetes and Thyroid Center, Kathmandu, Nepal., Pathan F; Department of Endocrinology, Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh., Nkansah DA; Department of Endocrinology, 37 Military Hospital Accra, Accra, Ghana.
Jazyk: angličtina
Zdroj: Diabetes therapy : research, treatment and education of diabetes and related disorders [Diabetes Ther] 2021 Feb; Vol. 12 (2), pp. 465-485. Date of Electronic Publication: 2020 Dec 26.
DOI: 10.1007/s13300-020-00973-0
Abstrakt: Diabetes mellitus is a global health concern associated with significant morbidity and mortality. Inadequate control of diabetes leads to chronic complications and higher mortality rates, which emphasizes the importance of achieving glycemic targets. Although glycated hemoglobin (HbA 1c ) is the gold standard for measuring glycemic control, it has several limitations. Therefore, in recent years, along with the emergence of continuous glucose monitoring (CGM) technology, glycemic control modalities have moved beyond HbA 1c . They encompass modern glucometrics, such as glycemic variability (GV) and time-in-range (TIR). The key advantage of these newer metrics over HbA 1c is that they allow personalized diabetes management with person-centric glycemic control. Basal insulin analogues, especially second-generation basal insulins with properties such as longer duration of action and low risk of hypoglycemia, have demonstrated clinical benefits by reducing GV and improving TIR. Therefore, for more effective and accurate diabetes management, the development of an integrated approach with second-generation basal insulin and glucometrics involving GV and TIR is the need of the hour. With this objective, a multinational group of endocrinologists and diabetologists reviewed the existing recommendations on TIR, provided their clinical insights into the individualization of TIR targets, and elucidated on the role of the second-generation basal insulin analogues in addressing TIR.
Databáze: MEDLINE
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