Event-related potential and EEG oscillatory predictors of verbal memory in mild cognitive impairment.

Autor: Xia J; Center for Mind and Brain and Neurology Department, University of California, Davis, CA, USA., Mazaheri A; School of Psychology, University of Birmingham, Birmingham, UK.; Center for Human Brain Health, University of Birmingham, Birmingham, UK., Segaert K; School of Psychology, University of Birmingham, Birmingham, UK.; Center for Human Brain Health, University of Birmingham, Birmingham, UK., Salmon DP; Department of Neurosciences, University of California, San Diego, CA, USA., Harvey D; Department of Public Health Sciences, University of California, Davis, CA, USA., Shapiro K; School of Psychology, University of Birmingham, Birmingham, UK.; Center for Human Brain Health, University of Birmingham, Birmingham, UK., Kutas M; Department of Neurosciences, University of California, San Diego, CA, USA.; Department of Cognitive Sciences, University of California, San Diego, CA, USA., Olichney JM; Center for Mind and Brain and Neurology Department, University of California, Davis, CA, USA.
Jazyk: angličtina
Zdroj: Brain communications [Brain Commun] 2020 Dec 10; Vol. 2 (2), pp. fcaa213. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).
DOI: 10.1093/braincomms/fcaa213
Abstrakt: Reliable biomarkers of memory decline are critical for the early detection of Alzheimer's disease. Previous work has found three EEG measures, namely the event-related brain potential P600, suppression of oscillatory activity in the alpha frequency range (∼10 Hz) and cross-frequency coupling between low theta/high delta and alpha/beta activity, each of which correlates strongly with verbal learning and memory abilities in healthy elderly and patients with mild cognitive impairment or prodromal Alzheimer's disease. In the present study, we address the question of whether event-related or oscillatory measures, or a combination thereof, best predict the decline of verbal memory in mild cognitive impairment and Alzheimer's disease. Single-trial correlation analyses show that despite a similarity in their time courses and sensitivities to word repetition, the P600 and the alpha suppression components are minimally correlated with each other on a trial-by-trial basis (generally | r s | < 0.10). This suggests that they are unlikely to stem from the same neural mechanism. Furthermore, event-related brain potentials constructed from bandpass filtered (delta, theta, alpha, beta or gamma bands) single-trial data indicate that only delta band activity (1-4 Hz) is strongly correlated ( r = 0.94, P < 0.001) with the canonical P600 repetition effect; event-related potentials in higher frequency bands are not. Importantly, stepwise multiple regression analyses reveal that the three event-related brain potential/oscillatory measures are complementary in predicting California Verbal Learning Test scores (overall R 2 ' s in 0.45-0.63 range). The present study highlights the importance of combining EEG event-related potential and oscillatory measures to better characterize the multiple mechanisms of memory failure in individuals with mild cognitive impairment or prodromal Alzheimer's disease.
(© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze: MEDLINE
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