Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences.
| Autor: | Mohanty S; Surgical Robotics Laboratory, Department of Biomechanical Engineering, University of Twente, 7522 NB Enschede, The Netherlands., Khalil ISM; Surgical Robotics Laboratory, Department of Biomechanical Engineering, University of Twente, 7522 NB Enschede, The Netherlands., Misra S; Surgical Robotics Laboratory, Department of Biomechanical Engineering, University of Twente, 7522 NB Enschede, The Netherlands.; Surgical Robotics Laboratory, Department of Biomedical Engineering, University Medical Center Groningen, 9713 AV Groningen, The Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Proceedings. Mathematical, physical, and engineering sciences [Proc Math Phys Eng Sci] 2020 Nov; Vol. 476 (2243), pp. 20200621. Date of Electronic Publication: 2020 Nov 18. |
| DOI: | 10.1098/rspa.2020.0621 |
| Abstrakt: | Acoustic actuation techniques offer a promising tool for contactless manipulation of both synthetic and biological micro/nano agents that encompass different length scales. The traditional usage of sound waves has steadily progressed from mid-air manipulation of salt grains to sophisticated techniques that employ nanoparticle flow in microfluidic networks. State-of-the-art in microfabrication and instrumentation have further expanded the outreach of these actuation techniques to autonomous propulsion of micro-agents. In this review article, we provide a universal perspective of the known acoustic micromanipulation technologies in terms of their applications and governing physics. Hereby, we survey these technologies and classify them with regards to passive and active manipulation of agents. These manipulation methods account for both intelligent devices adept at dexterous non-contact handling of micro-agents, and acoustically induced mechanisms for self-propulsion of micro-robots. Moreover, owing to the clinical compliance of ultrasound, we provide future considerations of acoustic manipulation techniques to be fruitfully employed in biological applications that range from label-free drug testing to minimally invasive clinical interventions. Competing Interests: We declare we have no competing interests. (© 2020 The Author(s).) |
| Databáze: | MEDLINE |
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