Lung mechanics in type L CoVID-19 pneumonia: a pseudo-normal ARDS.

Autor: Viola L; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Russo E; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Benni M; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Gamberini E; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Circelli A; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Bissoni L; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Santonastaso DP; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Scognamiglio G; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Bolondi G; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy., Mezzatesta L; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy.; University of Messina, Messina, Italy., Agnoletti V; U.O. Anestesia e Rianimazione, Ospedale 'M. Bufalini' Hospital, 286, Viale Ghirotti, Cesena, Italy.
Jazyk: angličtina
Zdroj: Translational medicine communications [Transl Med Commun] 2020; Vol. 5 (1), pp. 27. Date of Electronic Publication: 2020 Dec 21.
DOI: 10.1186/s41231-020-00076-9
Abstrakt: Background: This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long as to explore its variations during prone positioning.
Methods: We enrolled four patients hospitalized in the Intensive Care Unit of "M. Bufalini" hospital, Cesena (Italy); after the positioning of an esophageal balloon, we measured mechanical power, respiratory system and transpulmonary parameters and arterial blood gases every 6 hours, just before decubitus change and 1 hour after prono-supination.
Results: Both respiratory system and transpulmonary compliance and driving pressure confirmed the pseudo-normal respiratory mechanics of early CoVID-19 pneumonia (respectively, C RS 40.8 ml/cmH 2 O and DP RS 9.7 cmH 2 O; C L 53.1 ml/cmH 2 O and DP L 7.9 cmH 2 O). Interestingly, prone positioning involved a worsening in respiratory mechanical properties throughout time (C RS,SUP 56.3 ml/cmH 2 O and C RS,PR 41.5 ml/cmH 2 O - P 0.37; C L,SUP 80.8 ml/cmH 2 O and C L,PR 53.2 ml/cmH 2 O - P 0.23).
Conclusions: Despite the severe ARDS pattern, respiratory system and lung mechanical properties during CoVID-19 pneumonia are pseudo-normal and tend to worsen during pronation.
Trial Registration: Restrospectively registered.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s) 2020.)
Databáze: MEDLINE
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