Clinical features and radiological manifestations of COVID-19 disease.

Autor:	Landete P; Department of Pulmonology, H. U. La Princesa, Madrid 28006, Spain., Quezada Loaiza CA; Department of P ulmonology, H. 12 de Octubre, Madrid 28041, Spain., Aldave-Orzaiz B; Department of Pulmonology, H. U. La Princesa, Madrid 28006, Spain., Muñiz SH; Department of Radiologist, H. U. La Princesa, Madrid 28006, Spain., Maldonado A; Department of Nuclear Medicine, Hospital Universitario Quironsalud Madrid, Madrid 28223, Spain., Zamora E; Department of Pulmonology, H. U. La Princesa, Madrid 28006, Spain., Sam Cerna AC; Department of Pulmonology, Hospital MD Anderson Madrid. España, Madrid 28033, Spain., Del Cerro E; Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, Madrid 28223, Spain., Alonso RC; Department of Diagnostic Imaging, Hospital Universitario Quirón Madrid, Madrid 28223, Spain., Couñago F; Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, Madrid 28223, Spain.
Jazyk:	angličtina
Zdroj:	World journal of radiology [World J Radiol] 2020 Nov 28; Vol. 12 (11), pp. 247-260.
DOI:	10.4329/wjr.v12.i11.247
Abstrakt:	Coronavirus disease 2019 (COVID-19) was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province (China). Coronavirus is a family of single-stranded RNA viruses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted from person to person. Although asymptomatic individuals can transmit the virus, symptomatic patients are more contagious. The incubation period ranges from 3-7 d and symptoms are mainly respiratory, including pneumonia or pulmonary embolism in severe cases. Elevated serum levels of interleukins (IL)-2, IL-6, IL-7 indicate the presence of cytokine release syndrome, which is associated with disease severity. The disease has three main phases: Viral infection, pulmonary involvement, and hyperinflammation. To date, no treatment has proved to be safe or effective. Chest X-ray and computed tomography (CT) are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia, follow-up, and detection of complications. The main radiological findings are ground-glass opacification and areas of consolidation. The long-term clinical course is unknown, although some patients may develop pulmonary fibrosis. Positron emission tomography-computed tomography (PET-CT) is useful to assess pulmonary involvement, to define the affected areas, and to assess treatment response. The pathophysiology and clinical course of COVID-19 infection remain poorly understood. However, patterns detected on CT and PET-CT may help to diagnose and guide treatment. In this mini review, we analyze the clinical manifestations and radiological findings of COVID-19 infection. Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest. (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu