Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology.

Autor:	Lage C; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., González-Suárez A; Neurology Service, Laredo Hospital, Laredo, Spain., Alcalde-Hierro MP; Anesthesiology Service, 'Marqués de Valdecilla' University Hospital, Santander, Spain., Sampedro-González MI; Anesthesiology Service, 'Marqués de Valdecilla' University Hospital, Santander, Spain., Villanueva-Eguaras MÁ; Anesthesiology Service, 'Marqués de Valdecilla' University Hospital, Santander, Spain., Sánchez-Crespo MR; Traumatology Service, 'Marqués de Valdecilla' University Hospital, Santander, Spain., Widmann C; University of Bonn Medical Center, Department of Neurodegenerative Diseases & Geropsychiatry/Neurology, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Brosseron F; University of Bonn Medical Center, Department of Neurodegenerative Diseases & Geropsychiatry/Neurology, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Pozueta A; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., López-García S; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., García-Martínez M; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., Kazimierczak M; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., Bravo-González M; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., Fernández-Rodríguez A; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., Drake-Pérez M; Radiology Service, 'Marqués de Valdecilla' University Hospital, Santander, Spain., Irure-Ventura J; Immunology Service, 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., López-Hoyos M; Immunology Service, 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., Rodríguez-Rodríguez E; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain., Heneka MT; University of Bonn Medical Center, Department of Neurodegenerative Diseases & Geropsychiatry/Neurology, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Sánchez-Juan P; Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 'Marqués de Valdecilla' University Hospital, University of Cantabria, Institute for Research 'Marqués de Valdecilla' (IDIVAL), Santander, Spain.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 79 (2), pp. 863-874.
DOI:	10.3233/JAD-191229
Abstrakt:	Background: Major surgery has been associated with perioperative neurocognitive disorders (PND), but the contributing factors and long-term prognosis are uncertain. We hypothesize that preclinical Alzheimer's disease (AD) might predispose to cognitive deterioration after surgery. Objective: To analyze the effect of amyloid-β on the cognitive trajectory after orthopedic surgery in a sample of non-demented subjects. Methods: Non-demented individuals older than 65 years that were on the waiting list for orthopedic surgery with spinal anesthesia underwent a neuropsychological assessment before and after surgery. During surgery, cerebrospinal fluid samples were obtained to determine AD biomarkers. Results: Cumulative incidence of PND was 55.2%during a mean follow-up of nine months. The most affected cognitive domains were executive function and constructional praxis. The presence of abnormal levels of amyloid-β was associated to a postoperative impairment in verbal and visual memory tests. According to their AD biomarker profile, participants were categorized as either Amyloid Positive (A+) or Amyloid Negative (A-). The incidence of PND did not differ between both groups. The A- group showed a tendency similar to the global sample, worsening in executive function tests and improving on memory scales due to practice effects. In contrast, the A + group showed a notable worsening on memory performance. Conclusion: Our findings support the hypothesis that surgery may promote or accelerate memory decline in cognitively asymptomatic subjects with brain amyloid-β deposits.
Databáze:	MEDLINE
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