Chopping the tail: How preventing superspreading can help to maintain COVID-19 control.

Autor: Kain MP; Department of Biology, Stanford University, Stanford, CA, 94305, USA; Natural Capital Project, Woods Institute for the Environment, Stanford University, Stanford, CA 94305, USA. Electronic address: morganpkain@gmail.com., Childs ML; Emmett Interdisciplinary Program in Environment and Resources, Stanford University, Stanford, CA, 94305, USA. Electronic address: marissac@stanford.edu., Becker AD; Department of Biology, Stanford University, Stanford, CA, 94305, USA., Mordecai EA; Department of Biology, Stanford University, Stanford, CA, 94305, USA.
Jazyk: angličtina
Zdroj: Epidemics [Epidemics] 2021 Mar; Vol. 34, pp. 100430. Date of Electronic Publication: 2020 Dec 21.
DOI: 10.1016/j.epidem.2020.100430
Abstrakt: Disease transmission is notoriously heterogeneous, and SARS-CoV-2 is no exception. A skewed distribution where few individuals or events are responsible for the majority of transmission can result in explosive, superspreading events, which produce rapid and volatile epidemic dynamics, especially early or late in epidemics. Anticipating and preventing superspreading events can produce large reductions in overall transmission rates. Here, we present a stochastic compartmental (SEIR) epidemiological model framework for estimating transmission parameters from multiple imperfectly observed data streams, including reported cases, deaths, and mobile phone-based mobility that incorporates individual-level heterogeneity in transmission using previous estimates for SARS-CoV-1 and SARS-CoV-2. We parameterize the model for COVID-19 epidemic dynamics by estimating a time-varying transmission rate that incorporates the impact of non-pharmaceutical intervention strategies that change over time, in five epidemiologically distinct settings-Los Angeles and Santa Clara Counties, California; Seattle (King County), Washington; Atlanta (Dekalb and Fulton Counties), Georgia; and Miami (Miami-Dade County), Florida. We find that the effective reproduction number (R E ) dropped below 1 rapidly in all five locations following social distancing orders in mid-March, 2020, but that gradually increasing mobility starting around mid-April led to an R E once again above 1 in late May (Los Angeles, Miami, and Atlanta) or early June (Santa Clara County and Seattle). However, we find that increased social distancing starting in mid-July in response to epidemic resurgence once again dropped R E below 1 in all locations by August 14. We next used the fitted model to ask: how does truncating the individual-level transmission rate distribution (which removes periods of time with especially high individual transmission rates and thus models superspreading events) affect epidemic dynamics and control? We find that interventions that truncate the transmission rate distribution while partially relaxing social distancing are broadly effective, with impacts on epidemic growth on par with the strongest population-wide social distancing observed in April, 2020. Given that social distancing interventions will be needed to maintain epidemic control until a vaccine becomes widely available, "chopping off the tail" to reduce the probability of superspreading events presents a promising option to alleviate the need for extreme general social distancing.
(Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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